Reference

Oral composition in the form of a combined iron-bacteria preparation particularly intended for treating animals

Oral composition in the form of a combined iron-bacteria preparation particularly intended for treating animals.Some chemicals with cas registry numbers like 10124-49-9 and 31516-56-0 are also used. Kvanta, Endre (Aktiebolag Medipharm, Swed.). PCT Int. Appl. WO 8303352 A1 13 Oct 1983, 12 pp. DESIGNATED STATES: W: DK, FI, HU, NO, SU, US; RW: AT, BE, CH, DE, FR, GB, LU, NL, SE. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: IC: A61K009-06. APPLICATION: WO 83-SE119 29 Mar 1983. PRIORITY: SE 82-2017 30 Mar 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A combined Fe-bacteria oral compn. for animals comprises a bacteria conc., esp. lactic acid-producing bacteria, Fe compds., hydrophobic substances in a nonaq. ointment base, and preservatives, etc. An example compn. contains a bacteria conc. in powd. form contg. 1 ′ 109 living bacteria/g 2.0, iron dextran [9004-66-4] 60, mixed fats 48, starch 8, milk powder 4 and antioxidant (vitamin E) 0.1 g. The compn. is packaged in a tube to be squeezed into the mouth of the animals. .

Effect of antioxidants on lipid peroxidation in iron-loaded rats

Effect of antioxidants on lipid peroxidation in iron-loaded rats. Dillard, Cora J.; Downey, Jeanne E.; Tappel, Al L. (Dep. Food Sci. Technol., Univ. California, Davis, CA 95616, USA). Lipids, 19(2), 127-33 (English) 1984. CODEN: LPDSAP. ISSN: 0024-4201. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) As a measure of lipid peroxidn., pentane expired in the breath of rats loaded with an accumulated dose of either 100 mg or 186-200 mg of Fe injected i.p. as Fe dextran [9004-66-4] was measured over a 7-8 wk period, and the effect on pentane prodn. of feeding antioxidant-supplemented diets was detd. By the 7th week of feeding the diets, rats fed 0.3% L-ascorbic acid [50-81-7] produced 17% less pentane than did rats fed the basal antioxidant-deficient diet, whereas rats fed 0.004% dl-a-tocopherol acetate [52225-20-4] produced 92% less. After being fed the basal diet for 7 wk, Fe-loaded rats produced 76 pmol pentane/100 g body wt/min. When synthetic antioxidants were added to the diet at a concn. of 0.25%, the order of effectiveness in decreasing pentane prodn. after 1 wk was: N,N'-diphenyl-p-phenylenediamine [74-31-7] > ethoxyquin [91-53-2] > BHA [25013-16-5] > BHT [128-37-0] > propyl gallate [121-79-9] u no antioxidant. After removal of either ethoxyquin or N,N'-diphenyl-p-phenylenediamine from the diets for 1 wk, pentane prodn. increased to a high level. The total amt. of lipid-sol. 128-37-0 and 121-79-9 which are cas registry numbers of substances are two of reagents here. fluorophores in individual spleens of rats fed N,N'-diphenyl-p-phenylenediamine, ethoxyquin, dl-a-tocopherol acetate, ascorbic acid, and no antioxidant were correlated significantly with the corresponding total integrated amt. of pentane produced by the individual rats over the 7-8 wk period. This study has provided some of the most direct evidence to date that lipid peroxidn. is assocd. with Fe overload in vivo. .