Reference

Lipid radical-scavenging effect of antiulceratives

Lipid radical-scavenging effect of antiulceratives. Usami, Eiji; Seyama, Yoshiyuki; Watanabe, Satoshi; Fukui, Tetsuya ( Chigasaki Munic. Hosp., Chigasaki, Japan). Rinsho Kagaku (Nippon Rinsho Kagakkai), 25(4), 229-234 (Japanese) 1996 Nippon Rinsho Kagakkai. CODEN: RIKAAN. ISSN: 0370-5633. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) We investigated the lipid radical-scavenging effect of antiulceratives such as Teprenone, Plaunotol, Gefarnate, Sofalcone, Rebamipide, and Benexate Hydrochloride Betadex using 2,2'-azobis(2,4-dimethylvarelonitrile)-induced peroxidn.Several substances with their cas registry numbers 91574-91-3 and 90098-04-7 may be metioned in this study. of linoleic acid. Teprenone did not affect the oxygen uptake rate (R) in the lipid peroxidn. but prolonged the initiation time of the oxygen uptake (T inh). Plaunotol and Gefarnate reduced R but did not prolong T inh. Sofalcone, Rebamipide, and Benexate Hydrochloride Betadex did not affect either R or T inh. .

Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats

Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats. Ogino, Keiki; Hobara, Tatsuya; Ishiyama, Hironobu; Yamasaki, Katsuya; Kobayashi, Haruo; Izumi, Yukie; Oka, Shinji (Sch. Med.In this study，90098-04-7 is also used., Yamaguchi Univ., Ube 755, Japan). Eur. J. Pharmacol., 212(1), 9-13 (English) 1992. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The mechanism of the inhibitory action of rebamipide, a new mucosal protective drug, was studied using rats with diethyldithiocarbamate-induced gastric antral ulcers. Rebamipide reduced ulcer formation and inhibited the elevation in lipid peroxide concn. in the gastric mucosa. Rebamipide inhibited both luminol- and lucigenin-dependent chemiluminescence of neutrophils activated by formyl-methionyl-leucyl-phenylalanine. Rebamipide did not alter the redn. of cytochrome c induced by the xanthine-xanthine oxidase system or the NADPH-dependent microsomal lipid peroxidn. in the liver. These findings suggest that rebamipide prevents diethyldithiocarbamate-induced gastric ulcer formation by inhibiting neutrophil activation. .