Detail of "9033-53-8"

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Tissue vitamin A repletion is impaired by exposure to carcinogen

Tissue vitamin A repletion is impaired by exposure to carcinogen. Edes, Thomas E.; Kwan, Sandra M.; Buckley, Christopher S.; Thornton, William H., Jr. (Dep. Med., Harry S. Truman Mem. Veterans Hosp., Columbia, MO 65201, USA). Int. J. Cancer, 50(1), 99-102 (English) 1992. CODEN: IJCNAW. ISSN: 0020-7136. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) This study was designed to det. 9033-53-8 is just another one chemical used in this study. whether benzo[a]pyrene (BP) exposure affects tissue vitamin A nutriture. Female Sprague-Dawley rats were randomized to purified diets, sufficient or deficient in vitamin A, and with or without 200 mg BP/kg feed. Lack of dietary vitamin A resulted in a profound decrease in vitamin A in the serum, liver and lungs. No histol. changes were evident in any tissues examd. Serum vitamin A was not affected by dietary BP. In vitamin-A-sufficient rats, dietary BP caused a significant decline in hepatic and lung vitamin A. In rats fed vitamin-A-deficient diets, dietary BP had no effect on tissue vitamin A. Evidently, the chronic exposure to the carcinogen BP leads to tissue depletion of vitamin A, despite a vitamin-A-sufficient diet. BP impairs tissue repletion by metabolizing incoming vitamin A rather than in situ vitamin A, since BP had no effect on tissue vitamin A levels in rats fed a diet devoid of vitamin A. This BP-induced vitamin depletion may eventually have a deleterious effect on epithelial tissue health, and may help to explain the assocn. between vitamin A and cigaret-smoke-related cancers.Except for chemicals metioned above, 50-32-8 and 68-26-8 are also used. ..