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| CAS No.: | 9036-06-0 |
|---|---|
| Name: | EC 3.4.24.4 |
| Molecular Structure: | |
|
|
|
| Formula: | NULL |
| Molecular Weight: | 0 |
| Synonyms: | s.Griseusproteinase;Streptomycesgriseusprotease;Streptomycesgriseusproteinase;ACTINASE E, STREPTOMYCES GRISEUS;ACTINASE E;EC 3.4.24.4;EC 3.4.24.31;EC 3.4.24.32 |
| EINECS: | 232-966-6 |
| Solubility: | H2O: 5-20 mg/mL |
| Appearance: | slightly brown powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 36/37/38-42 |
| Safety: | 22-24-26-36/37-24/25 |
| PSA: | 0.00000 |
| LogP: | 0.00000 |
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Specification
The Pronase, with the CAS registry number 9036-06-0, is also known as S. griseus protease. Its EINECS registry number is 232-966-6. What's more, this chemical's classification codes are Drug / Therapeutic Agent; Natural Product. Pronase is a commercially available mixture of proteinases isolated from the extracellular fluid of Streptomyces griseus. Activity extends to both denatured and native proteins leading to complete or nearly complete digestion into individual amino acids. The product should be sealed and stored in dry and well-ventilated place at the temperature of -20 °C.
Uses of Pronase: it can be used in biochemical research. This chemical has strong reactions of protein hydrolysis which can hydrolysis fibrin and sticky protein. This product is only used for scientific research.
When you are using this chemical, please be cautious about it as the following:
This chemical may cause damage to health. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing and gloves.
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 14100ug/kg (14.1mg/kg) | Drugs in Japan Vol. 6, Pg. 730, 1982. | |
| mouse | LD50 | intravenous | 20500ug/kg (20.5mg/kg) | Drugs in Japan Vol. 6, Pg. 730, 1982. | |
| mouse | LD50 | oral | 4010mg/kg (4010mg/kg) | Drugs in Japan Vol. 6, Pg. 730, 1982. | |
| mouse | LD50 | subcutaneous | 26800ug/kg (26.8mg/kg) | Drugs in Japan Vol. 6, Pg. 730, 1982. | |
| rabbit | LD50 | oral | 1243ku/kg (1243000iu/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 364, 1995. | |
| rat | LD50 | intraperitoneal | 16200ug/kg (16.2mg/kg) | Drugs in Japan Vol. 6, Pg. 730, 1982. | |
| rat | LD50 | intravenous | 15800ug/kg (15.8mg/kg) | Drugs in Japan Vol. 6, Pg. 730, 1982. | |
| rat | LD50 | oral | 3290mg/kg (3290mg/kg) | Drugs in Japan Vol. 6, Pg. 730, 1982. | |
| rat | LD50 | subcutaneous | 100mg/kg (100mg/kg) | Drugs in Japan Vol. 6, Pg. 730, 1982. |