Reference

Heparin web compositions

Heparin web compositions. Thiel, Charles G. (Riker Laboratories, Inc., USA). U.S. US 4405612 A 20 Sep 1983, 7 pp. Cont.-in-part of U.S. Ser. No. 152,751, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-725; D04H001-04; C08B037-10. NCL: 424183000. APPLICATION: US 81-267579 21 May 1981. PRIORITY: US 80-152751 23 May 1980. DOCUMENT TYPE: Patent CA Section: 9 (Biochemical Methods) Section cross-reference(s): 63 Microfibers of amorphous heparin salts are spun onto a collector to form an open, nonwoven web. The heparin salt soln. is spun into a fluid (air, N, or iso-PrOH) at a preferable fluid/soln. ratio of . The webs can be used for rapid heparinizing of blood samples for anal., esp. for blood gas anal. The samples are not dild. by a heparin soln., and the heparin soln. rate is rapid (<1 s).There are some commonly used reagents with their cas registry numbers 54479-70-8 and 37270-89-6 in this article. Thus, 10 g heparin Na [9041-08-1] in 15 g H2O was pumped through an 18 gage hypodermic needle by using the syringe, and the soln. was blown by compressed air (3400 N/m2) through a 6.35-mm-diam. nozzle. The microfibers were dried with hot air and collected on a screen. The web dissolved instantly in H2O and in <1 s in blood. The web did not affect blood pH. .

Observed stability of heparin in dextrose 5%

Observed stability of heparin in dextrose 5%. Moyle, Robert S.; Cain, Michael J. (Pharm. Dep., Sir Charles Gairdner Hosp., Nedlands 6009, Australia). Aust. J. Hosp. Pharm., 13(3), 124 (English) 1983. CODEN: AUHPAI. ISSN: 0310-6810. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Na heparin [9041-08-1] solns., contg. 2500 units and 12,500 units of the anticoagulant and prepd. in dextrose [50-99-7] (5%) for injection, showed no measurable loss of heparin activity over 47 h at room temp. The accuracy of the assay used for heparin estn. indicated that the actual loss was between 0-10%. This is within the British Pharmacopeia limits for heparin and would allow a 24-h expiration to be used for these solns.