Detail of "90419-12-8"

Reference

The neuropeptide Y Y1 receptor selective radioligand, [125I][Leu31,Pro34]peptide YY, is also a high affinity radioligand for human pancreatic polypeptide 1 receptors

The neuropeptide Y Y1 receptor selective radioligand, [125I][Leu31,Pro34]peptide YY, is also a high affinity radioligand for human pancreatic polypeptide 1 receptors. Gehlert, Donald R.; Gackenheimer, Susan L.; Schober, Douglas A.; Beavers, Lisa; Gadski, Robert; Burnett, J. Paul; Mayne, Nancy; Lundell, Ingrid; Larhammar, Dan (Central Nervous System and Endocrine Research, Mail Code 0510, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA). European Journal of Pharmacology, 318(2/3), 485-490 (English) 1996 Elsevier. CODEN: EJPHAZ. ISSN: 0014-2999.Several reagents with their cas registry numbers 90880-35-6 and 90419-12-8 are used here. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) A no. of receptors for the pancreatic polypeptide-fold peptides are proposed based on findings from pharmacol. and mol. biol. studies. Neuropeptide Y and peptide YY have similar affinity for neuropeptide Y Y1 and neuropeptide Y Y2 while pancreatic polypeptide has highest affinity for pancreatic polypeptide 1. Pro34-substituted analogs of neuropeptide Y and peptide YY have selectivity for neuropeptide Y Y1 over neuropeptide Y Y2 receptors. In the present study, the authors found that one such 'neuropeptide Y Y1-selective' radioligand, [125I][Leu31,Pro34]peptide YY, also binds with high affinity to the pancreatic polypeptide 1 receptor. Therefore, caution needs to be exercised when using Pro34-analogs to define the neuropeptide Y Y1 receptor in vivo and using tissue prepns. .

Differences in cation sensitivity of ligand binding to Y1 and Y2 subtype of neuropeptide Y receptor of rat brain

Differences in cation sensitivity of ligand binding to Y1 and Y2 subtype of neuropeptide Y receptor of rat brain.Some chemicals with cas registry numbers like 1404-04-2 and 90419-12-8 are also used. Parker, Michael S.; Crowley, William R.; Parker, Steven L. (Dep. Pharmacol., Univ. Tennessee Coll. Med., Memphis, TN, USA). European Journal of Pharmacology, 318(1), 193-200 (English) 1996 Elsevier. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The binding of selective ligands to the Y1 subtype of neuropeptide Y receptor in rat brain particulates was promoted by Ca2+ and also stimulated by Sr2+, but reversibly reduced by Ba2+, Mg2+, Mn2+, by the org. polycations neomycin and spermidine, and by chelating agents. The alkali monovalent cations inhibited the Ca2+-enabled Y1 subtype binding with some selectivity (Cs+ 3 NH4+ > Li+ > Na+,K+), with half-inhibition between 70-120 mM. The specific Y2 subtype binding was enhanced by all alk.-earth divalent cations, Mn2+, neomycin and spermidine in the range of 0.1-10 mM, and by alkali cations at up to 100 mM, and also by Na+ salts of the chelators EGTA and EDTA. The large disparity in cation sensitivity indicates substantial differences in the structure of the binding sites of the Y1 and Y2 receptors, predictable from known distinct features of ligand epitopes and of primary structure of the receptors. .