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| CAS No.: | 9050-31-1 |
|---|---|
| Name: | Hydroxypropyl methylcellulose phthalate |
| Molecular Structure: | |
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| Formula: | C8H6O4.xC3H8O2.xCH4O.xUnspecified |
| Molecular Weight: | 240.30400 |
| Synonyms: | HP 50F;HP 55F;HP 55UF;HPMCP;Hypromellose phthtalate (NF);Hydroxypropylmethylcellulose phthalate;HP 50 (cellulose derivative);Hypromellose phthtalate;Cellulose,esters,hydrogen 1,2-benzenedicarboxylate,2-hydroxypropyl methyl ether;Hydroxypropylmethylcellulose phthalate (JP14);HPMCP 55;Hydroxypropylmethyl Cellulose phthalate（HPMCP）;Hydroxy propyl Methyl cellulose Phthalate (HPMCP-HP55); |
| EINECS: | 232-674-9 |
| Density: | 0.6 g/mL at 25oC(lit.) |
| Melting Point: | >145oC (dec.)(lit.) |
| Boiling Point: | 456.7°C at 760 mmHg |
| Flash Point: | 230°C |
| Appearance: | White Powder |
| Safety: | 24/25 |
| PSA: | 57.46000 |
| LogP: | 2.75280 |
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Specification
The systematic name of Hydroxypropyl methylcellulose phthalate is Cellulose, hydrogen 1,2-benzenedicarboxylate, 2-hydroxypropyl methyl ether. With the CAS registry number 9050-31-1, it is also named as HP 55. The other registry numbers are 168395-88-8, 37324-31-5, 42612-68-0, 52624-22-3 and 9087-42-7. And the classification code is TSCA Flag XU [Exempt from reporting under the Inventory Update Rule]. It is white to off-white free-flowing flakes or granules which is stable under normal temperatures and pressures. Additionally, Hydroxypropyl methylcellulose phthalate should be sealed in the container and stored in the cool and dry place. Besides, people should avoid contact with skin and eyes.
The following are the toxicity data which has been tested.
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD | oral | > 15gm/kg (15000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA | Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1017, 1970. |