Reference

Treatment of tumors with glucan compositions in mice and rats

Treatment of tumors with glucan compositions in mice and rats. Komatsu, Nobuhiko; Sakai, Sumio; Saito, Gosaku; Kikumoto, Syoichi; Kimura, Keitaro (Kaken Chemical Co., Ltd.; Taito Co., Ltd., Japan). U.S. US 3987166 19 Oct 1976, 8 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-70. NCL: 424180000. APPLICATION: US 68-766630 10 Oct 1968. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 16 Malignant tumors are treated with compns. contg. a glucan [9051-97-2]. 302-70-5 and 50-07-7 which are cas registry numbers are also used here. Thus glucan was prepd. by fermn. of Humfeld's basal medium, glucose, urea and thiamine-HCl with Schizophyllum commune. Saline solns. contg. 5, 2.5, 1.25, and 0.625 mg/kg glucan, injected i.p. into mice, pretreated with s.c. injections of sarcoma 37 ascites cells, showed tumor inhibition ratios (av. tumor wt. of treated mice compared to controls) of 94, 87, 90 and 71%, resp. .

Beads of water-insoluble

Beads of water-insoluble .beta.-1,3-glucan gels. Miyashiro, Yutaka; Ogawa, Masao; Yamazaki, Yoshio; Igarasi, Seizi (Takeda Chemical Industries, Ltd., Japan). Ger. Offen. DE 2646879 5 May 1977, 29 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C08L005-02. PRIORITY: JP 75-127196 21 Oct 1975. DOCUMENT TYPE: Patent CA Section: 44 (Industrial Carbohydrates) Stirring aq. alk. .beta.-1,3-glucan (I) [9051-97-2] of Alcaligenes faecalis myxogenes in org. solvents in the presence of surfactants gave I beads for use as carriers in gel filtration. Thus, a suspension of 6 g powd. I in 270 mL H2O was treated with 6 g surfactant, 30 mL 1N NaOH, and 1200 mL PhMe, stirred at 800 rpm, treated with 2000 mL PhMe and 100 mL AcOH, and stirred to give 250 mL I gels having particle diam. of 30-100 .mu. and 100-300 .mu. in 46.8% and 53.2%, resp.