Detail of "90580-64-6"

Reference

Neutron capture preparation and use thereof

All Rights Reserved. Neutron capture preparation and use thereof. Yanagie, Hironobu; Eriguchi, Masazumi; Nishimura, Ryohei; Higashi, Syushi; Kajiyama, Tetsuya (Japan ). PCT Int. Appl. WO 2007013600 A1 1 Feb 2007,40pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (Japanese). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-JP315007 28 Jul 2006. PRIORITY: JP 2005-221612 29 Jul 2005. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) In order to improve the safety of neutron capture therapy, a neutron capture prepn. is provided which can be accumulated in a tumor cell at a good level. A boron compd. is used as a neutron-capturing agent. 90580-64-6 and 144885-51-8 are cas registry numbers of chemicals which are used as reagents here. A W/O/W-type emulsion is formed which is composed of an inner aq. phase contg. the boron compd., an oily phase and an outer aq. phase, and the emulsion can be used as the neutron capture prepn. Examples of the boron compd. include borocaptate (BSH) and p-boronophenylalanin. For example, a W/O/W emulsion was prepd. from BSH, lactose hydrate, iodinated oil (Lipiodol), polyoxyethylene hydrogenated castor oil (HCO40 and HCO60), and NaCl soln., and examd. for its accumulation in liver tumor. .

Synthesis of boronated phenylalanine analogs with a quaternary center for boron neutron capture therapy

Synthesis of boronated phenylalanine analogs with a quaternary center for boron neutron capture therapy. Zaidlewicz, Marek; Cytarska, Joanna; Dzielendziak, Adam; Ziegler-Borowska, Marta (Department of Chemistry, Nicolaus Copernicus University, Torun 87-100, Pol.). ARKIVOC (Gainesville, FL, United States), (3), 11-21 (English) 2004 Arkat USA Inc. URL: http://www. 90580-64-6 is the cas registry number. This chemical is also mentioned in this article.arkat-usa.org/ark/journal/2004/Makosza/MM-857G/857G.pd f. CODEN: AGFUAR. DOCUMENT TYPE: Journal; (online computer file) CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 8 DL-2-Amino-2-methyl-3-(4-dihydroxyborylphenyl)propionic acid (I) and 1-amino-3-(4-dihydroxyborylbenzyl)cyclobutanecarboxylic acid (II), which are DL-p-boronophenylalanine analogs contg. a quaternary center, were synthesized from 4-allylbromobenzene. Also, I was prepd. from DL-alanine, and the route is generally suitable for the synthesis of a-alkyl-BPA analogs. Both I and II exhibit very similar Rf values indicating similar lipophilicities.Chemical with cas number 90580-64-6 also plays role. The products were prepd. as potential boron carriers for boron neutron capture therapy. ..