Detail of "9062-10-6"

Reference

Pharmaceutical dosage form with multiple polymer coatings for reduced impact of coating fractures

Pharmaceutical dosage form with multiple polymer coatings for reduced impact of coating fractures. Newby, Daniel Gary; Cronk, Tony Ryan; Amante, Joseph Michael; Dittmar, Gregory Paul (The Procter & Gamble Company, USA). Can. Pat. Appl. CA 2444814 AA 20 May 2002, 24 pp., Division of Can. Pat. Appl. 2,359,812. (English). (Canada). CODEN: CPXXEB. CLASS: ICM: A61K031-616. ICS: A61P029-00; A61K009-22; A61K009-30. APPLICATION: CA 2001-2444814 24 Oct 2001. PRIORITY: CA 2001-2359812 24 Oct 2001. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The present invention relates to a pharmaceutical compn. in a solid unit dosage form for oral administration in a human or lower animal comprising (a) a safe and effective amt. of a therapeutically active agent; (b) an inner coating layer selected from the group consisting of poly(methacrylic acid, Me methacrylate) 1:2, poly(methacrylic acid, Me methacrylate) 1:1, and mixts. thereof; and (c) an outer coating layer comprising an enteric polymer or film coating material; wherein the inner coating layer is not the same as the outer coating layer; wherein if the inner coating layer is poly(methacrylic acid, Me methacrylate) 1:1 then the outer coating layer is not poly(methacrylic acid, Me methacrylate) 1:2 or is not a mixt. of poly(methacrylic acid, Me methacrylate) 1:1 and poly(methacrylic acid, Me methacrylate) 1:2; and wherein the inner coating layer and the outer coating layer do not contain any therapeutically active agent. This invention further relates to a method of maintaining the desired site of delivery of a therapeutic agent in the gastrointestinal tract by administering the above compns. to a human or lower animal. For example, a compn. contg. Insulin 20 IU (about 1 mg), Sodium 5-methoxysalicylate 150.0 mg, PEG 4000 3.5 mg and PEG 600 mg was encapsulated within soft or hard gelatin capsules. Capsules were spray coated with an inner layer comprising Eudragit S100 70 g, tri-Et citrate 14 g, acetone 283 g, and iso-Pr alc. 483 g to a thickness of about 100 m dried coating. Following the application of the inner coating, an outer coating layer comprising Eudragit L100 42 g, Eudragit S100 28 g, tri-Et citrate 14 g, acetone 283 g, and iso-Pr alc. 9062-10-6 which is the cas registry number of some chemical is mentioned. 483 g was spray coated to a thickness of about 20 m. .