Detail of "90954-53-3"

Reference

Calcitonin gene-related peptide is a potent vasodilator

Calcitonin gene-related peptide is a potent vasodilator. Brain, S. D.; Williams, T. J.; Tippins, J. R.; Morris, H. R.; MacIntyre, I. (Inst. Basic Med. Sci., R. Coll. Surg. England, London WC2A 3PN, UK). Nature (London), 313(5997), 54-6 (English) 1985. CODEN: NATUAS. ISSN: 0028-0836. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Both human calcitonin gene-related peptide (hCGRP) [90954-53-3] and rat calcitonin gene-related peptide (rCGRP) [83651-90-5], injected intradermally in fmol doses, increased blood flow in rabbit skin with potencies similar to that of PGE2 [363-24-6]. The increased blood flow response to hCGPR in rabbit skin was not altered by preinjection of the treatment sites with indomethacin. In human skin, the intradermal injection of hCGRP (15 pmol) caused a persistent hyperemia. Microscopic observations in the hamster cheek pouch show that hCGRP causes arteriolar dilation. In rat aortic rings contg. endothelial cells, hCGRP caused relaxation, but not when endothelial cells were absent. Thus, CGRP may be involved in the regulation of blood flow and may contribute to hyperemia in certain pathol. conditions.

Vasomotor responses of cerebral veins in animals and man

Vasomotor responses of cerebral veins in animals and man. Hardebo, J. E.; Kaahrstroem, J.; Sercombe, R.; Owman, C.; Salford, L. G.; Verrecchia, C. (Dep. Histol., Univ. Lund, Lund, Swed.). Fernstroem Found. Ser., 8(Neural Regul.In this article, certain chemicals are used. Some of their cas registry numbers are 7683-59-2 and 51-45-6 Brain Circ.), 481-95 (English) 1986. CODEN: FFOSDF. ISSN: 0167-7004. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Pial veins were isolated from rats, rabbits, cows, monkeys, and humans, and their responsiveness to various vasoactive agents was examd. Noradrenaline [51-41-2] caused contraction in all veins with ED50 values ranging 3 ′ 10-7-2 ′ 10-6M. The response was mediated by a-adrenergic receptors. Serotonin [50-67-9] elicited contraction mediated by 5-HT2 receptors in all veins, and acetylcholine [51-84-3] caused contraction in all veins except those from the cow and monkey. The contractile response to acetylcholine in the human pial vein was not obsd. unless the endothelium was removed. Histamine [51-45-6] contracted only the rabbit pial vein and neuropeptide Y [82785-45-3] contracted the human and rabbit pial vein. PGF2a [551-11-1] contracted pial veins from all species as did K+ depolarization; however, the response to K+ of the human pial vein was transient. In precontracted pial veins, isoprenaline [7683-59-2], VIP [37221-79-7], acetylcholine, and histamine were without effect. PGE1 [745-65-3] caused dilation in noradrenaline-contracted human veins and substance P [33507-63-0] caused a minor relaxation in human veins. Rat [83651-90-5] and human calcitonin gene-related peptide [90954-53-3] were strong dilators in all veins tested. Bradykinin [58-82-2] was also a strong dilator of human veins. The Ca2+ antagonists nimodipine [66085-59-4], diltiazem [42399-41-7], and D-600 [16662-47-8] produced variable dilations dependent on the contractile agent used. .