Reference

Products formed from analogues of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) metabolites by Pseudomonas putida

Products formed from analogues of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) metabolites by Pseudomonas putida. Subba-Rao, R. V.; Alexander, M. (Dep. Agron., Cornell Univ., Ithaca, N. Y., USA). Appl. Environ. Microbiol., 33(1), 101-8 (English) 1977. CODEN: AEMIDF. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Cultures of P. putida growing in solns. with diphenylmethane [101-81-5] as sole carbon source formed 1,1,1',1'-tetraphenyldimethyl ether [574-42-5]. The product was identified by gas chromatog., mass spectrometry, and IR and NMR spectrometry. The formation of benzophenone [119-61-9], benzhydrol [91-01-0], and phenylglycolic acid [90-64-2] was established by gas chromatog. and mass spectrometry. Similar techniques also revealed that phenylacetic acid [103-82-2] was a major metabolite. Resting cell suspensions coverted benzhydrol to phenylglycolic acid and products tentatively identified as hydroxybenzhydrols and a hydroxybenzophenone. Cell suspensions of the bacterium also converted the tetraphenyldimethyl ether to benzhydrol and benzophenone. Possible pathways for the degrdn. of these analogues of DDT metabolites are discussed.

Determination of renally excreted benzhydrol and its glucuronide

Determination of renally excreted benzhydrol and its glucuronide. Potential metabolites of diphenylmethylether and diphenylmethylamine derivatives. Dell, H. D.; Fiedler, J. (Biochem. Abt., Troponwerke, Cologne, Ger.). Fresenius' Z. Anal. Chem., 284(2), 126-7 (German) 1977. CODEN: ZACFAU. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The potential drug metabolite benzhydrol [91-01-0], administrated orally (10 mg) to rabbits, was recovered in the urine as its glucuronide [62875-13-2] with a 64.3% yield in 48 h. After oral administration of cinnarizine (I) [298-57-7] or diphenylpyraline (II) [147-20-6], which are metabolized to benzhydrol, benzhydrol glucuronide was recovered in rabbit urine in 3.6 and 3.4% yield, resp., on a molar basis. Benzhydrol was detd. in the urine by enzymic hydrolysis of the glucuronide, extn. into CHCl3, thin-layer chromatog., elution, oxidn. to benzophenone, and UV spectrophotometry.