Reference

The effect of N-phenylanthranilic acid-induced renal papillary necrosis on urinary acidification and renal electrolyte handling

The effect of N-phenylanthranilic acid-induced renal papillary necrosis on urinary acidification and renal electrolyte handling. Hardy, T. L.; Bach, Peter H. (Res. Div., Beecham Pharm., Harlow/Essex CM13 5AD, UK). Toxicol. Appl. Pharmacol., 75(2), 265-77 (English) 1984. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 14 The oral administration of a suspension of N-phenylanthranilic acid (N-PAA) [91-40-7] over the range of 0.5 to 2 mmol/kg for 14 consecutive days, caused a dose-related renal papillary necrosis (RPN), which involved no more than 30% of the medullary apex. This area of necrosis was no greater following daily doses of 3 and 5 mmol/kg of N-PAA for 14 days, but cortical degenerative changes were induced. The area of the necrotic lesion was greater in the left kidneys of individual rats than in the right kidneys. The apex-limited histopathol. changes assocd. with the administration of low doses of N-PAA were not reflected by altered electrolyte or water homeostasis and only high doses of N-PAA caused significant changes. Urinary vol. was significantly increased (in animals treated with 5 mmol/kg, whereas urinary osmolality (> 2 mmol/kg N-PAA), and Na+ (5 mmol/kg), K+ (5 mmol/kg), and Cl- (5 mmol/kg) excretion was decreased compared to controls. Blood urea nitrogen was increased at doses > 3 mmol/kg in assocn. with cortical degenerative changes. When untreated rats were dosed orally with NH4Cl (400 mg/kg) there was a lag period between 0 and 2 h (when no changes in H+ excretion occurred) but the urinary pH was depressed in the 2- to 4-h collection period. Only those rats treated with the highest dose of N-PAA (5 mmol/kg) showed a significantly impaired urinary acidification after NH4Cl loading. There was, however, a statistically significant dose-related decrease in the excretion of Cl- following NH4Cl dosing, provided urine was sampled between 0 and 2 h. These data highlight the failure of the commonly used renal function tests (such as urinary vol., osmolality, and electrolyte excretion) to reflect apex-limited RPN, unless cortical degenerative changes were also present. The dose-related depression of Cl- excretion in the 0-2-h period following oral NH4Cl loading, suggests that appropriately timed sampling of this urinary anion could offer an improved criterion for the diagnosis of RPN.

Inhibitor of lead oxidation for the negative electrode of a lead storage battery

Inhibitor of lead oxidation for the negative electrode of a lead storage battery. Yampol'skaya, E. G.; Smirnova, I. A.; Krasnolobova, Z. I.; Rozenfel'd, I. L.; Persiantseva, V. P.; Brusnikina, V. M.; Bocharov, B. V. (USSR ). U.S.S.R. SU 576629 15 Oct 1977 From: Otkrytiya, Izobret., Prom. Obraztsy, Tovarnye Znaki 1977, 54(38), 118. (Russian). (Union of Soviet Socialist Republics). CODEN: URXXAF. CLASS: IC: H01M004-62. APPLICATION: SU 76-2376664 22 Jun 1976. DOCUMENT TYPE: Patent CA Section: 52 (Electrochemical, Radiational, and Thermal Energy Technology) N-phenylanthranilic acid [91-40-7] is used as the oxidn. inhibitor for Pb-acid battery anodes.