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Detail of "910-86-1"

  • CAS Number:
  • 910-86-1
  • Name:

  • Thiourea,N,N'-bis[4-(3-methylbutoxy)phenyl]-

  • Molecular Structure:
  • Formula:
  • C23H32 N2 O2 S
  • Molecular Weight:
  • 400.5774
  • Synonyms:
  • Carbanilide,4,4'-bis(isopentyloxy)thio- (6CI,7CI,8CI);1,3-Bis[4-(isopentyloxy)phenyl]thiourea; 4,4'-Bis(isoamyloxy)thiocarbanilide;4,4'-Bis(isopentyloxy)thiocarbanilide; 4,4'-Di(isoamyloxy)thiocarbanilide;DATC; Datanil; Disocarban; Isoxyl; N,N'-Bis[p-(3-methylbutoxy)phenyl]thiourea;Thiocarlide; Tiocarlid; Tiocarlide; sym-Bis(4-isoamyloxyphenyl)thiourea
  • EINECS:
  • 213-006-5
  • Density:
  • 1.117 g/cm3
  • Boiling Point:
  • 508.5 °C at 760 mmHg
  • Flash Point:
  • 261.3 °C
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CAS No.910-86-1 Thiourea,N,N'-bis[4-(3-methylbutoxy)phenyl]-

Supplier:Cayman Chemical Company [ United States]

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Tel:(800) 364-9897

Address:1180 East Ellsworth Road Ann Arbor, Michigan 48108 USA

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Reference

The activity of thiacetazone, thiambutosine, thiocarlide and sulfamethoxypyridazine against Mycobacterium leprae in mice
The activity of thiacetazone, thiambutosine, thiocarlide and sulfamethoxypyridazine against Mycobacterium leprae in mice. Colston, M. J.; Hilson, G. R. F.; Ellard, G. A.; Gammon, Patricia T.; Rees, R. J. W. (St. George's Hosp. Med. Sch., London, Engl.). Lepr. Rev., 49(2), 101-13 (English) 1978. CODEN: LEREAA. ISSN: 0024-1032. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The mouse footpad model was used to evaluate the activity of thiambutosine [500-89-0], thiocarlide [910-86-1], thiacetazone [104-06-3] and sulfamethoxypyridazine [80-35-3] against M. leprae. The min. EDs of thiambutosine and thiocarlide were approx. 0.05% and of thiacetazone 0.03%, although different strains of M. leprae displayed varying sensitivity to all 3 drugs. The minimal inhibitory concns. of thiambutosine, thiacetazone, and sulphamethoxypyridazine were about 0.5 mg/mL, 0.2 mg/mL,and 30 mg/mL, resp. The antileprosy activity of thiambutosine, thiocarlide, and thiacetazone was essentially bacteriostatic. The clin. relevance of these findings is discussed.
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