Detail of "912-60-7"

Reference

Comparative bioavailability and pharmacokinetics of noscapine hydrogen embonate and noscapine hydrochloride

Comparative bioavailability and pharmacokinetics of noscapine hydrogen embonate and noscapine hydrochloride. Haikala, V.; Sothmann, A.; Marvola, M. (Univ. Pharm., Univ. Helsinki, Helsinki SF-00510, Finland). Eur. J. Clin. Pharmacol., 31(3), 367-9 (English) 1986. CODEN: EJCPAS. ISSN: 0031-6970. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 The relative bioavailability and pharmacokinetics of two orally administered aq. suspensions of noscapine hydrogen embonate [106611-48-7] were compared with those of a noscapine HCl [912-60-7] soln in volunteers. Noscapine HCl showed faster absorption and gave a higher peak concn. than the embonate. The av. bioavailability of the embonates was 70% of that of the noscapine soln. No significant difference was obsd. when the embonate was administered with water, polyvidone [9003-39-8] and flavoring agents.

Determination of antitussives, expectorants, and antihistaminic agents in anti-cold preparations by high-speed liquid chromatography

Determination of antitussives, expectorants, and antihistaminic agents in anti-cold preparations by high-speed liquid chromatography. Tatsuzawa, Masayoshi; Hashiba, Shigeko; Ejima, Akira (Natl. Inst. Hyg. Sci., Tokyo, Japan). Eisei Kagaku, 23(5), 282-9 (Japanese) 1977. CODEN: ESKGA2. ISSN: 0013-273X. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Glyceryl guaiacol ether [93-14-1], noscapine [128-62-1], noscapine-HCl [912-60-7], chlorpheniramine maleate [113-92-8], diphenhydramine salicylate [7491-10-3], diphenhydramine-HCl [147-24-0], promethazine methylenedisalicylate [66277-13-2], alimemazine tartrate [4330-99-8], and isothipendyl-HCl [1225-60-1] in anticold prepns. were sepd. successfully by styrene-divinylbenzene copolymer gel or poly(methacrylate) gel as a stationary phase and a mixt. of MeOH and conc. ammonia water as a mobile phase. The sepd. ingredients were detected by spectrophotometry using a UV monitor. Methylephedrine-HCl (I) [942-46-1] was undetected by this method because of its low sensitivity. It had to be sepd. from other ingredients by an ion-exchanger. The sepd. I was oxidized with K ferricyanide, chromatographed, and quantitated by substituting MeOH for the mixt. of MeOH and concd. ammonia water in this procedure.