Detail of "91296-87-6"

Reference

Implantation or injectable dosage form new animal drugs; sarafloxacin hydrochloride

Implantation or injectable dosage form new animal drugs; sarafloxacin hydrochloride. Haibel, George K. (Cent.Chemical with cas number 91296-87-6 also plays role. Vet. Med., FDA, Rockville, MD 20855, USA). Federal Register, 62(44), 10219-10220, 6 Mar 1997 (English) 1997 Superintendent of Documents. CODEN: FEREAC. ISSN: 0097-6326. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Sarafloxacin hydrochloride soln. may be used for injection in 18-day embryonated broiler eggs for control of early chick mortality assocd. with Escherichia coli organisms susceptible to sarafloxacin, under the Federal Food, Drug, and Cosmetic Act. .

Aerobic biodegradation of 14C-sarafloxacin hydrochloride in soil

Aerobic biodegradation of 14C-sarafloxacin hydrochloride in soil.Some chemicals with cas registry numbers like 91296-87-6 are also used. Marengo, Jose R.; Kok, Rebecca A.; O'Brien, Kelly; Velagaleti, Ranga R.; Stamm, John M. (Battelle, Columbus, OH 43201, USA). Environmental Toxicology and Chemistry, 16(3), 462-471 (English) 1997 SETAC Press. CODEN: ETOCDK. ISSN: 0730-7268. DOCUMENT TYPE: Journal CA Section: 19 (Fertilizers, Soils, and Plant Nutrition) Section cross-reference(s): 1 The aerobic biodegrdn. of sarafloxacin hydrochloride, a fluoroquinolone antibiotic registered for use against poultry diseases, was tested in three soils: loam, silt loam, and sandy loam. Sarafloxacin treatment demonstrated mineralization to 14CO2 amounting to 0.58%, 0.49%, and 0.57% in loam, silt loam, and sandy loam soils, resp., at the termination of the test. The extractability of sarafloxacin from soil in acetonitrile-water (ACN:H2O, 1:1, vol./vol.) was less than 1% of the applied radioactivity. This was followed by extn. with pipemidic acid (a quinolone with structural similarity to sarafloxacin) and KOH (PIP:KOH), which resulted in ~25% extractability in loam, ~73% in silt loam, and ~80% in sandy loam soils, with extractability increasing with decreasing org. matter content (5.8%, 2.5%, and 1.3%, resp., for the three soils). HPLC of ACN:H2O extractable radioactivity showed several components, all of which were less than 1% of the applied radioactivity. Hence, no attempt was made to characterize these components. The HPLC anal. of PIP:KOH exts. demonstrated two major components, one with a retention time of ~4 to 5 min (designated polar component), the other component, sarafloxacin, with a retention time of ~35 min. The components present in ACN:H2O or PIP:KOH exts. were not significantly different at day zero or at termination, prompting expts. that resulted in the following observations. Sarafloxacin std. exposed to extn. solvents (PIP:KOH and ACN:H2O) showed no degrdn., suggesting stability of the test article in extn. solvents. Component profiles in sterile soils were similar to those in nonsterile soils, suggesting that the formation of the polar degradate component of sarafloxacin is an abiotic phenomenon. Expts. conducted with sand spiked with sarafloxacin showed very little or no transformation, suggesting that the degrdn. is a soil-related phenomenon. The polar component was converted to sarafloxacin when the exts. were subjected to acid hydrolysis. .