Products Categories
CAS No.: | 913611-97-9 |
---|---|
Name: | Brexpiprazole |
Article Data: | 36 |
Molecular Structure: | |
Formula: | N/A |
Molecular Weight: | 433.574 |
Synonyms: | Brexpiprazole |
Density: | 1.245±0.06 g/cm3(Predicted) |
Melting Point: | 179 - 181oC |
Boiling Point: | 675.2±55.0 °C(Predicted) |
Brexpiprazole
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; water at 20 - 80℃; for 2h; | 96.1% |
Brexpiprazole
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane; water for 2h; | 96% |
Stage #1: 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one hydrochloride In ethanol; water Reflux; Stage #2: With pyrographite In ethanol; water for 0.5h; Reflux; Stage #3: With sodium hydride In ethanol; water for 0.5h; Reflux; | 3.76 kg |
With pyrographite In ethanol; water for 0.5h; Reflux; Large scale; | 3.76 kg |
Brexpiprazole
Conditions | Yield |
---|---|
Stage #1: 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride With sodium carbonate In methanol; water at 50℃; for 0.5h; Stage #2: 7-(4-chlorobutoxy)quinoline-2(1H)-one In methanol; water at 70℃; for 16h; | 95.5% |
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 70℃; for 10h; | 84% |
With potassium carbonate In ethanol; water at 40 - 50℃; | 82.3% |
4-chlorobenzothiophene
Brexpiprazole
Conditions | Yield |
---|---|
With C48H55ClN2Pd; sodium t-butanolate In 1,2-dimethoxyethane at 20℃; for 16h; Inert atmosphere; Sealed tube; | 95% |
4-bromo-1,3-benzothiazole
Brexpiprazole
Conditions | Yield |
---|---|
Stage #1: 4-bromobenzo[d]thiazole With isopropylmagnesium chloride In tetrahydrofuran at -5℃; for 2h; Stage #2: 7-(4-(piperazin-1-yl)butoxy)quinolin-2(1H)-one dihydrochloride In tetrahydrofuran for 3h; | 91.5% |
4-chlorobenzothiophene
Brexpiprazole
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; triphenylphosphine In 5,5-dimethyl-1,3-cyclohexadiene for 5h; Solvent; Reagent/catalyst; Inert atmosphere; Reflux; | 90% |
benzo[B]thiophen-4-ylamine
Brexpiprazole
Conditions | Yield |
---|---|
In butan-1-ol at 25 - 125℃; | 90% |
With potassium carbonate; potassium iodide In 5,5-dimethyl-1,3-cyclohexadiene at 130 - 140℃; | 78.5% |
Conditions | Yield |
---|---|
With sodium carbonate In acetonitrile for 23h; Reflux; | 88.3% |
7–(4-bromobutoxy)quinolin-2(1H)-one
Brexpiprazole
Conditions | Yield |
---|---|
Stage #1: 1-(benzo[b]thiophen-4-yl)piperazine dihydrochloride With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: 7–(4-bromobutoxy)quinolin-2(1H)-one With potassium iodide In N,N-dimethyl-formamide at 100℃; for 4h; Inert atmosphere; | 85% |
benzo[b]thiophen-4-ylboronic acid
Brexpiprazole
Conditions | Yield |
---|---|
With copper diacetate; triethylamine In dichloromethane at 0 - 35℃; Reagent/catalyst; Solvent; Temperature; | 83.3% |