Detail of "91478-09-0"

CAS Number:
91478-09-0
Name:
3(2H)-Pyridazinone,5-[(R)-(2,6-dichlorophenyl)hydroxymethyl]-4,5-dihydro-6-methyl-, (5S)-rel-
Molecular Structure:
Formula:
C12H12 Cl2 N2 O2
Molecular Weight:
0
Synonyms:
3(2H)-Pyridazinone,5-[(2,6-dichlorophenyl)hydroxymethyl]-4,5-dihydro-6-methyl-, (R*,S*)- (9CI);3(2H)-Pyridazinone,5-[(2,6-dichlorophenyl)hydroxymethyl]-4,5-dihydro-6-methyl-, (R*,S*)-(?à)-;
Density:
1.5g/cm³
Boiling Point:
°Cat760mmHg
Flash Point:
°C

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Chemical structure and hemodynamic effects of two new pyridazinone derivatives: Chemical structure and hemodynamic effects of two new pyridazinone derivatives. Eschalier, A.; Rodriguez, M.; Duchene-Marullaz, P.; Taoufik, J.; Couquelet, J.; Tronche, P. (Lab. Pharmacol. Med., Fac. Med., Clermont-Ferrand, Fr.). Farmaco, Ed. Sci., 40(3), 200-8 (English) 1985. CODEN: FRPSAX. ISSN: 0430-0920. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 Two new pyridazinone derivs. were selected among two series and assayed for their hemodynamic effects. Their synthesis is described and their chem. structure confirmed by IR and NMR data. (±)-erythro-5-[(2',6'-Dichlorophenyl)hydroxymethyl]-6-methyl-4,5-dihy dro(2H)-3-pyridazinone (I) [91478-09-0] did not induce any significant hemodynamic changes. However, E-5-[(2',6'-dichlorobenzylidene)]-6-methyl-(2H,4H)-3-pyridazinone (II) [96355-92-9] i.v. injected, was active in anesthetized dogs. Moderate doses of II induced modifications in the heart rate, left ventricular dP/dt max and femoral blood flow and resistance.