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915759-45-4

Basic Information
CAS No.: 915759-45-4
Name: Benzenesulfonamide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)-
Molecular Structure:
Molecular Structure of 915759-45-4 (Benzenesulfonamide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)-)
Formula: C18H19F3N2O4S2
Molecular Weight: 448.48
Synonyms: CS-0996;
Density: 1.50±0.1 g/cm3(Predicted)
Boiling Point: 601.1±65.0 °C(Predicted)
PSA: 109.10000
LogP: 5.44980
Synthetic route
558-30-5

2-methyl-1,2-epoxypropane

915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

915759-79-4

N-[1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
In ethanol Reflux;70%
683-57-8

bromo-acetic acid amide

915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

915761-37-4

2-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl)amino)piperidin-1-yl]acetamide

Conditions
ConditionsYield
With triethylamine53%
108-30-5

succinic acid anhydride

915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

915761-35-2

4-oxo-4-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl)amino)piperidin-1-yl]butanoic acid

Conditions
ConditionsYield
In ethanol at 150℃; for 0.166667h; Microwave irradiation;33%
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

540-51-2

2-bromoethanol

915760-45-1

N-[1-(2-hydroxyethyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 150℃; for 0.166667h; Microwave irradiation;30%
850568-54-6

(4-(tert-butoxycarbonyl)phenyl)boronic acid

915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

C29H31F3N2O6S2

Conditions
ConditionsYield
With copper diacetate; triethylamine
108-55-4

glutaric anhydride,

915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

915761-50-1

5-oxo-5-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl)amino)piperidin-1-yl]pentanoic acid

Conditions
ConditionsYield
In ethanol at 150℃; Microwave irradiation;
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

476362-71-7

C7H5ClN4O2S

915762-51-5

5-(phenylsulfonyl)-N-(1-([3-(2H-tetrazol-5-yl)phenyl]-sulfonyl)piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;
220210-56-0

3-(tert-butoxycarbonyl)phenylboronic acid

915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

C29H31F3N2O6S2

Conditions
ConditionsYield
With copper diacetate; triethylamine
5292-43-3

bromoacetic acid tert-butyl ester

915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

C24H29F3N2O6S2

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 120℃; for 0.166667h; Microwave irradiation;
55666-43-8

tert-butyl 3-bromopropionate

915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

C25H31F3N2O6S2

Conditions
ConditionsYield
With triethylamine
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