Reference

Lactam-substituted tetrazolethiol compounds

Lactam-substituted tetrazolethiol compounds. (Shionogi and Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 60067478 A2 17 Apr 1985 Showa, 11 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C07D403-04. ICA: C07D205-08; C07D207-416; C07D257-04. ICI: C07D403-04, C07D207-00, C07D257-00. APPLICATION: JP 83-176001 22 Sep 1983. 91807-59-9 which is the cas registry number of one of substances is just one of reagents here. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) The title tetrazole derivs. (I; R = H, alkyl; R1 = H, alkyl, aralkyl, etc.; R2 = H, HS-protecting group, salt-forming radical; Z = CH2, CO; m = 0-1) were prepd. Thus, 10 mmol CS2 was added to a soln. of 10 mmol 3-amino-2-pyrrolidone in EtOH contg. Me3N at 25-30% followed by 10 mmol MeI at room temp. to give 88% II, which (8 mmol) was heated with 11 mmol NaN3 in H2O at 80-90° to give 72% (±)-I (R = R1 = R2 = H, Z = CH2, m = 1). .