Detail of "92169-45-4"

CAS Number:
92169-45-4
Name:
Neuromedin N (swinespinal cord) (9CI)
Molecular Structure:
Formula:
C38H63 N7 O8
Molecular Weight:
745.95
Synonyms:
NeuromedinN (pig spinal cord); 10: PN: US6525021 SEQID: 9 unclaimed sequence; 372: PN:WO0069900 SEQID: 554 unclaimed sequence; 464: PN: US20090175821 SEQID: 554claimed protein; 5: PN: DE102005003687 SEQID: 3 unclaimed protein; 82: PN:WO2008058016 SEQID: 82 claimed protein; 9: PN: WO0023092 SEQID: 9 unclaimedsequence; Canine neuromedin N; L-Leucine, N-[N-[N-[1-(N-L-lysyl-L-isoleucyl)-L-prolyl]-L-tyrosyl]-L-isoleucyl]-;Mouse neuromedin N; Neuromedin N (dog); Neuromedin N (ox); Neuromedin N (rat);Porcine neuromedin N

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Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord: Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord. Minamino, Naoto; Kangawa, Kenji; Matsuo, Hisayuki (Dep. Biochem., Miyazaki Med. Coll., Miyazaki 889-16, Japan). Biochem. Biophys. Res. Commun., 122(2), 542-9 (English) 1984. CODEN: BBRCA9. ISSN: 0006-291X. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) A novel neurotensin-like peptide, designated neuromedin N [92169-45-4] was isolated from porcine spinal cord using a bioassay for a stimulant effect on guinea pig ileum. By microsequencing, the amino acid sequence of the peptide was detd. to be Lys-Ile-Pro-Tyr-Ile-Leu, which is be quite homologous to the C-terminal sequence of neurotensin. This structure was confirmed by synthesis. Neuromedin N exhibits a contractile activity on guinea pig ileum and induces a hypotensive response in the rat similar to that with neurotensin. Neuromedin N may be a new neuromediator or hormone with a specific spectrum of biol. activity.

Protection of tyrosine phenolic hydroxyl moiety with b,b,b-trichloroethoxycarbonyl (TROC) group: Protection of tyrosine phenolic hydroxyl moiety with b,b,b-trichloroethoxycarbonyl (TROC) group. Kiyama, Shinya; Ooi, Yoshihiro; Kitagawa, Kouki; Tsukamoto, Yukie; Akita, Tadashi (Fac. Pharm. Sci., Tokushima Univ., Tokushima 770, Japan).There are some reagents with their cas registry numbers 92169-45-4 and 17341-93-4 are used in this study. Pept. Chem., Volume Date 1985, 23rd, 121-4 (English) 1986. CODEN: PECHDP. ISSN: 0388-3698. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Me3CO2C-Tyr(Troc)-OH was prepd. and used in the solid-phase synthesis of peptides H-Tyr-Ile-Asn-Gly-OH and H-Lys-Ile-Pro-Tyr-Ile-Leu-OH (neuromedin N). The Troc group was cleaved by Zn in CF3CO2H. .