Reference

Muramyl peptide phosphatidylethanolamine derivatives for the prevention and treatment of virus infections

Muramyl peptide phosphatidylethanolamine derivatives for the prevention and treatment of virus infections. Lukas, Bohumir; Schmidt-Ruppin, Karl Heinz (Ciba-Geigy A.-G. , Switz.). Ger. Offen. 83461-56-7 and 90297-70-4 are also occured in this study. DE 3326163 A1 26 Jan 1984, 81 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: A61K031-70. APPLICATION: DE 83-3326163 20 Jul 1983. PRIORITY: CH 82-4528 23 Jul 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 33, 34 Muramyl peptide phosphatidylethanolamine derivs. are effective in the prevention and treatment of infections caused by DNA and RNA viruses of various classes. The antiviral compds. can be formulated as tablets and capsules contg. 0.1-0.9% active ingredient or as topical prepns. (including eye and nose drops and lipsticks) contg. 0.001-1% active ingredient. Thus, N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine 2-(1,2-dipalmitoyl-sn-glycero-3-hydroxyphosphoryloxy)ethylamide Na salt (I Na salt) [90297-67-9] was prepd. from the condensation of 2-(1,2-dipalmitoyl-sn-glycero-3-hydroxyphosphoryloxy)ethylamine [923-61-5] and N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine N-hydroxysuccinimide ester [90297-68-0] in the presence of N-acetylmorpholine at room temp. The compd. was purified by filtration, diafiltration, and dialysis. Nose drops were prepd. contg. I 0.15 mg. The therapeutic and prophylactic effects of oral and intranasal, resp., administration of 0.005% I in aq. Na CM-cellulose was demonstrated in guinea pigs infected with herpes simplex 2 virus intravaginally. The effectiveness of this and other phosphatidylethanolamine derivs. of muramyl peptides against influenza, other herpes and other infections were demonstrated. .

X-ray studies on phospholipid bilayers

X-ray studies on phospholipid bilayers. V. Interactions with DDT. Suwalsky, M.; Bugueno, N.; Tapia, J.; Neira, F. (Dep. Quimica, Univ. Concepcion, Concepcion, Chile). Z. Naturforsch., C: Biosci., 40C(7-8), 566-70 (English) 1985. CODEN: ZNCBDA. ISSN: 0341-0382. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The possible interaction of DDT (I) [50-29-3] with the lipids L-a-dimyristoyl lecithin [18194-24-6], L-a-dipalmitoylphosphatidylethanolamine [923-61-5] and tripalmitin [555-44-2] was studied. The work was carried out on oriented films and cryst. powders of I-lipid mixts. at different molar ratios by x-ray diffraction techniques. The diagrams showed only the patterns of pure I and that of the corresponding lipid. Thus, new phases were not formed and, therefore, no interactions occurred.