Detail of "92623-85-3"

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Differential Blockade of Nerve Injury-Induced Shift in Weight Bearing and Thermal and Tactile Hypersensitivity by Milnacipran

All Rights Reserved. Differential Blockade of Nerve Injury-Induced Shift in Weight Bearing and Thermal and Tactile Hypersensitivity by Milnacipran. King, Tamara; Rao, Srinivas; Vanderah, Todd; Chen, Qingmin; Vardanyan, Anna; Porreca, Frank (Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA). Journal of Pain, 7(7), 513-520 (English) 2006 Elsevier Inc. CODEN: JPOAB5. ISSN: 1526-5900. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 63 Antidepressants such as tricyclic antidepressants have become used to treat a variety of chronic pain conditions. However, the side effects are dose-limiting in the treatment of chronic pain. Milnacipran is a norepinephrine/serotonin reuptake inhibitor that does not have the severe side effects assocd. with traditional tricyclic antidepressants. The effects of intrathecal and systemic administration of milnacipran on spinal nerve ligation (SNL)-induced thermal and mech. hypersensitivity and shift in wt. bearing were detd. Intrathecal administration of milnacipran was found to reverse both SNL-induced thermal and tactile (to von Frey filaments) hypersensitivity, as well as shift in wt. bearing. Acute systemic administration of milnacipran also reversed nerve injury-induced thermal hypersensitivity for up to 5 h but failed to reverse tactile hypersensitivity or shift in wt. bearing. Of note, both intrathecal and s.c. administration of milnacipran induced thermal antinociception in both SNL and sham rats. Chronic (daily) systemic administration of milnacipran alleviated both thermal hypersensitivity and shift in wt. bearing, with both acute and chronic effects obsd. on thermal hypersensitivity. However, chronic systemic milnacipran administration failed to alleviate tactile hypersensitivity to von Frey filaments. These results indicate that different mechanisms underlie shift in wt. bearing, thermal hypersensitivity, and tactile hypersensitivity.In this experiment, several chemicals are used like 92623-85-3 Perspective: These results indicate that the ability of milnacipran to relieve nerve injury-induced allodynia, hyperalgesia, and shift in wt. bearing depends on the route of administration and the duration of treatment, with alleviation of SNL-induced tactile hypersensitivity and shift in wt. bearing as a result of activity within the central-rather than the peripheral-nervous system. .

Plasma levels of adiponectin and tumor necrosis factor-alpha in patients with remitted major depression receiving long-term maintenance antidepressant therapy

All Rights Reserved. Plasma levels of adiponectin and tumor necrosis factor-alpha in patients with remitted major depression receiving long-term maintenance antidepressant therapy. Narita, Kosuke; Murata, Tetsuhito; Takahashi, Tetsuya; Kosaka, Hirotaka; Omata, Naoto; Wada, Yuji (Department of Neuropsychiatry, University of Fukui, Fukui 910-1193, Japan). Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30(6), 1159-1162 (English) 2006 Elsevier B.V. CODEN: PNPPD7. ISSN: 0278-5846. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Adiponectin, an adipose tissue-specific plasma protein, is involved in insulin sensitization and has anti-atherosclerotic properties, whereas tumor necrosis factor-a (TNF-a), a pro-inflammatory protein, plays important roles in inflammatory endothelial injury and atherosclerotic changes. It has been reported that adiponectin and TNF-a inhibit each other's expression and prodn. in adipocytes. Several in vitro studies indicated that antidepressant medications decreased the prodn. of pro-inflammatory cytokines including TNF-a, but the effect of antidepressants on the expression of adiponectin is still unknown. We examd. the plasma levels of TNF-a and adiponectin in patients with remitted depression receiving maintenance antidepressant therapy for longer than half a year, and compared the levels with those in healthy controls. The plasma levels of TNF-a and adiponectin in the remitted depression group were significantly lower and higher than those in the control group, resp. This preliminary cross-sectional study suggests the possibility that maintenance antidepressant therapy may have anti-inflammatory effects and prevent the development of atherosclerosis.Except for chemicals metioned above, 54739-18-3 and 92623-85-3 are also used. .