Reference

Structure-activity relations in a series of analogs of e-aminocaproic acid

Structure-activity relations in a series of analogs of e-aminocaproic acid. Shibut, V. P.; Zabelin, N. N.; Golubovich, V. P.; Akhrem, A. A. (Inst. Bioorg. Khim., Minsk, USSR). Vestsi Akad. Navuk BSSR, Ser. Khim. Navuk, (2), 69-74 (Russian) 1986. CODEN: VBSKAK. ISSN: 0002-3590. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 22 By means of empirical energy calcns. 60-32-2 which is the cas registry number of some chemical is mentioned., all low-energy conformations of e-aminocaproic acid [60-32-2] and its analogs g-aminobutyric acid [56-12-2], d-aminovaleric acid [660-88-8], w-aminoenanthic acid [929-17-9], 4-aminobenzoic acid [150-13-0], 4-aminomethylbenzoic acid [56-91-7], 4-aminoethylbenzoic acid [1199-68-4], 4-aminophenylacetic acid [1197-55-3], and 4-aminomethylphenylacetic acid [1200-05-1] were detd. Comparison of these detns. with what is known about the antifibrinolytic activities of these compds. makes possible some predictions concerning the biol. active conformation of e-aminocaproic acid when it complexes with fibrinolytic enzymes. The distance between the NH2 and CO2H groups is crit., but the immediate environment of the NH2 group is also very important. .

Purification and crystallization of bacterial

Purification and crystallization of bacterial .omega.-amino acid-pyruvate aminotransferase. Yonaha, K.; Toyama, S.; Yasuda, M.In this study， 61461-61-8 and 929-17-9 are also used.; Soda, K. (Dep. Agric. Biol. Chem., Ryukyu Univ., Naha, Japan). FEBS Lett., 71(1), 21-4 (English) 1976. CODEN: FEBLAL. DOCUMENT TYPE: Journal CA Section: 7 (Enzymes) .omega.-Amino acid-pyruvate aminotransferase (I) was purified in 28% yield from Pseudomonas species F-126 and crystd. Purified I was homogeneous by the criteria of disc gel electrophoresis and ultracentrifugation. The mol. wt. of I was detd. by gel filtration to be .apprx.178,000. The pH optimum was 8.0-8.5 with .beta.-alanine as substrate. The relative activities of amino donors was: .beta.-alanine, 100; DL-.beta.-aminobutyric acid, 96.4; 3-aminopropanesulfonate, 79.8; .beta.-aminoisobutyric acid, 54.2, .gamma.-aminobutyric acid, 39.7; 7-aminoheptanoic acid, 35.2; taurine, 3.6; and glycine, 0.36. .alpha.-Ketoglutarate was inert as amino acceptor. I was inhibited by phenylhydrazine, hydroxylamine, D-cycloserine, and aminooxyacetate. .