Reference

Quantitative determinations of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in an expectorant by high-pressure liquid chromatography

Quantitative determinations of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in an expectorant by high-pressure liquid chromatography. Das Gupta, V.; Ghanekar, A. G. (Coll. Pharm., Univ. Houston, Houston, Tex., USA). J. Pharm. Sci., 66(6), 895-7 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The quant. detns. of codeine phosphate (I) [52-28-8], guaifenesin [93-14-1], pheniramine maleate [132-20-7], phenylpropanolamine-HCl [154-41-6], and pyrilamine maleate [59-33-6] in a liq. dosage form are described. All active and inactive ingredients (Na benzoate and FD&C Yellow No. 5 dye) can be sepd. with high-pressure liq. chromatog. on a monomol. layer of octadecyltrichlorosilane bonded to Si-C using 0.05M KH2PO4 in water contg. 13% (vol./vol.) MeOH as the solvent except the 2 antihistamines, pheniramine maleate and pyrilamine maleate. Pheniramine maleate is detd. either by difference or spectrophotometrically. The methods are simple, short, accurate, and precise. The std. deviations are reported.

A gas chromatographic method for the quantitative determination of glyceryl guaiacolate, methyl-p-hydroxybenzoate and propyl-p-hydroxybenzoate in cough mixture

A gas chromatographic method for the quantitative determination of glyceryl guaiacolate, methyl-p-hydroxybenzoate and propyl-p-hydroxybenzoate in cough mixture. Jensen, Fred (Nor. Apot. Forsoekslab., Oslo, Norway). Medd. Nor. Farm. Selsk., 39(1), 38-48 (English) 1977. CODEN: MNFSAW. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Simultaneous quant. detn. of glyceryl guaiacolate (I) [93-14-1], Me p-hydroxybenzoate (II; R=Me) [99-76-3] and Pr p-hydroxybenzoate (II; R=Pr) [94-13-3] in cough mixts. was carried out, after extn. with CHCl3, by derivatization with trimethylchlorosilane and hexamethyldisilazane, and subsequent gas chromatog. of the silyl derivs. on a column of 3% OV-1 on Gas-Chrom Q (60-80 mesh). Relative std. deviations were 1-2%. Of some possible degrdn. products tested, none interfered with the method.