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Basic Information
| CAS No.: | 93-51-6 |
|---|---|
| Name: | 2-Methoxy-4-methylphenol |
| Article Data: | 183 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H10O2 |
| Molecular Weight: | 138.166 |
| Synonyms: | Creosol(6CI);p-Cresol, 2-methoxy- (8CI);2-Methoxy-p-cresol;3-Methoxy-4-hydroxytoluene;4-Hydroxy-3-methoxy-1-methylbenzene;4-Hydroxy-3-methoxytoluene;4-Methyl-2-methoxyphenol;4-Methylguaiacol;Homoguaiacol;NSC 4969;p-Creosol;p-Methylguaiacol; |
| EINECS: | 202-252-9 |
| Density: | 1.078 g/cm3 |
| Melting Point: | 5 °C(lit.) |
| Boiling Point: | 220 °C at 760 mmHg |
| Flash Point: | 99.4 °C |
| Solubility: | Slightly soluble in water. |
| Appearance: | Clear colorless to slightly yellow liquid |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 22-36/37/38 |
| Safety: | 26-36-24/25 |
| PSA: | 29.46000 |
| LogP: | 1.70920 |
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Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| With formic acid; palladium and silver nanoparticles over graphitic carbon nitride surface In water at 20℃; for 4h; Catalytic behavior; Reagent/catalyst; Temperature; Sealed tube; Irradiation; | 100% |
| With hydrogen; acetic acid; palladium on activated charcoal at 55℃; for 24h; | 99% |
| With hydrogen In water at 150℃; under 3750.38 Torr; for 5h; Reagent/catalyst; Temperature; Pressure; Time; Solvent; Autoclave; | 99.8% |
Conditions
| Conditions | Yield |
|---|---|
| With hydrogen In water at 70℃; Catalytic behavior; | A 99.9% B n/a |
| With hydrogen In water at 20 - 100℃; under 3750.38 Torr; for 1h; Kinetics; Reagent/catalyst; Temperature; Pressure; Autoclave; | A 90.9% B 9.1% |
| With 2 wt% Pd/C; hydrogen In water at 20 - 100℃; under 3750.38 Torr; for 1h; Kinetics; Reagent/catalyst; Autoclave; | A 21.8% B 78.3% |
Conditions
| Conditions | Yield |
|---|---|
| With Methyl formate; copper(l) chloride In methanol at 110℃; for 2h; Autoclave; | 98% |
| In methanol at 200℃; under 120012 Torr; for 0.0333333h; Temperature; Pressure; Time; Autoclave; | 13.38 g |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 4-hydroxymethyl-2-methoxyphenol With ammonium formate In ethanol; water at 22℃; for 0.166667h; Stage #2: With formic acid In ethanol; water at 22℃; for 1h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; chemoselective reaction; | 95% |
| With lithium aluminium tetrahydride In tetrahydrofuran; chlorobenzene for 3h; Heating; | 87% |
| With triethylsilane; palladium dichloride In ethanol at 20℃; for 0.166667h; Inert atmosphere; | 96 %Chromat. |
- 201359-55-9
1-(allyloxy)-2-methoxy-4-methylbenzene
- 93-51-6
2-Methoxy-4-methylphenol
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 1-(allyloxy)-2-methoxy-4-methylbenzene With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 2h; Inert atmosphere; Stage #2: With methanol In diethyl ether; pentane at -78℃; Inert atmosphere; | 88% |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 4-hydroxy-3-methoxyphenylacetonitrile With 15-crown-5; sodium In tetrahydrofuran; hexane at 0℃; for 0.333333h; Birch Reduction; Inert atmosphere; Stage #2: With water In tetrahydrofuran; hexane at 0℃; for 1h; Birch Reduction; Inert atmosphere; Stage #3: With hydrogenchloride In water pH=1; chemoselective reaction; | 84% |
| Stage #1: 4-hydroxy-3-methoxyphenylacetonitrile With 15-crown-5; sodium In tetrahydrofuran; hexane at 0℃; for 0.333333h; Inert atmosphere; Stage #2: With water In tetrahydrofuran; hexane at 0℃; for 1h; | 74% |
- 100-84-5
1-methoxy-3-methyl-benzene
A
- 93-51-6
2-Methoxy-4-methylphenol
B
- 5307-05-1
1-hydroxy-4-methoxy-2-methylbenzene
C
- 2896-67-5
2-methyl-6-methoxyphenol
Conditions
| Conditions | Yield |
|---|---|
| With wild type cytochrome P450 CYP102A1 variants RLYF/A330P; oxygen; NADPH Reagent/catalyst; Enzymatic reaction; | A 11% B 80% C 7% |
...Expand
- 93-51-6
2-Methoxy-4-methylphenol
Conditions
| Conditions | Yield |
|---|---|
| With chlorobis(ethylene)rhodium(I) dimer; hydrogen In 1,4-dioxane at 150℃; under 7757.43 Torr; Pressure; Reagent/catalyst; | 79% |
- 108439-89-0
Propionic acid 2-methoxy-4-methyl-phenyl ester
A
- 93-51-6
2-Methoxy-4-methylphenol
B
- 91970-98-8
hydroxy-5 methoxy-4 methyl-2 propiophenone
C
- 108439-90-3
propionyloxy-5 methoxy-4 methyl-2 propiophenone
Conditions
| Conditions | Yield |
|---|---|
| With aluminium trichloride In dichloromethane at 20℃; for 8h; | A 32% B 59% C 4% |
| With aluminium trichloride In dichloromethane at 0℃; for 8h; | A 32% B 49% C 20% |
...Expand
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 2-(2-methoxy-4-methylphenoxy)acetic acid With diphenyl-phosphinic acid; triethylamine In N,N-dimethyl-formamide; toluene for 3h; Curtius-rearrangement; Heating; Stage #2: With water In N,N-dimethyl-formamide; toluene Heating; Further stages.; | 59% |
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2-Methoxy-4-methylphenol
Chemistry
MF: C8H10O2
MW: 138.16
EINECS: 202-252-9
2-METHOXY-p-CRESOL(93-51-6),its melting point is 5 °C(lit.),boiling point is 221-222 °C(lit.);density is 1.092 g/mL at 25 °C(lit.) , Following is the molecular structure of 2-METHOXY-p-CRESOL(93-51-6):
MW: 138.16
EINECS: 202-252-9
2-METHOXY-p-CRESOL(93-51-6),its melting point is 5 °C(lit.),boiling point is 221-222 °C(lit.);density is 1.092 g/mL at 25 °C(lit.) , Following is the molecular structure of 2-METHOXY-p-CRESOL(93-51-6):
Uses
2-METHOXY-p-CRESOL(93-51-6) can be used for spice, pharmaceutical and other organic intermediates.
Toxicity Data With Reference
| 1. | sce-hmn:lyms 500 µmol/L | MUREAV Mutation Research. 206 (1988),17. | ||
| 2. | orl-rat LD50:740 mg/kg | FOMDAK Folia Medica. 32 (1991),309. | ||
| 3. | ivn-mus LD50:76 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 164 (1966),30. |
RTECS :GP1755000
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
A poison by intravenous route. Appears to be at least moderately toxic. An irritant to skin and eyes. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Othersafty informations about 2-METHOXY-p-CRESOL(93-51-6):
Hazard Codes : Xn,Xi (Harmful;Irritant)
Risk Statements :
R22:Harmful if swallowed
R36/37/38 :Irritating to eyes, respiratory system and skin
Safety Statements :
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical a
S36:Wear suitable protective clothing
S24/25 :Avoid contact with skin and eyes
RIDADR :2810
WGK Germany: 3
Othersafty informations about 2-METHOXY-p-CRESOL(93-51-6):
Hazard Codes : Xn,Xi (Harmful;Irritant)
Risk Statements :
R22:Harmful if swallowed
R36/37/38 :Irritating to eyes, respiratory system and skin
Safety Statements :
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical a
S36:Wear suitable protective clothing
S24/25 :Avoid contact with skin and eyes
RIDADR :2810
WGK Germany: 3