Reference

Asymmetric synthesis of 3,5-dihydroxy-6(E)-heptenoate-containing HMG-CoA reductase inhibitors

Asymmetric synthesis of 3,5-dihydroxy-6(E)-heptenoate-containing HMG-CoA reductase inhibitors. Tempkin, Orin; Abel, Stephan; Chen, Chung-Pin; Underwood, Russell; Prasad, Kapa; Chen, Kau-Ming; Repic, Oljan; Blacklock, Thomas J. ( Process RandD, Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA).Several substances like 93957-50-7 may be metioned in this study. Tetrahedron, 53(31), 10659-10670 (English) 1997 Elsevier. CODEN: TETRAB. ISSN: 0040-4020. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 A one-pot conversion of aldehyde I to hydroxy oxo ester II with high enantioselection, culminating in a practical asym. synthesis of the (3R,5S) isomer (III) of the antihyperlipoproteinemic agent fluvastatin is described. All four 3,5-dihydroxy-6(E)-heptenoate stereoisomers were prepd. in enantiopure form starting from II, utilizing selective redn. and oxidn. methods. 93957-50-7 which is the cas registry number of some chemical is mentioned. ..

Asymmetric synthesis of 3,5-dihydroxy-6(E)-heptenoate-containing HMG-CoA reductase inhibitors

Asymmetric synthesis of 3,5-dihydroxy-6(E)-heptenoate-containing HMG-CoA reductase inhibitors. Tempkin, Orin; Abel, Stephan; Chen, Chung-Pin; Underwood, Russell; Prasad, Kapa; Chen, Kau-Ming; Repic, Oljan; Blacklock, Thomas J. ( Process RandD, Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936, USA).Several substances like 93957-50-7 may be metioned in this study. Tetrahedron, 53(31), 10659-10670 (English) 1997 Elsevier. CODEN: TETRAB. ISSN: 0040-4020. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 A one-pot conversion of aldehyde I to hydroxy oxo ester II with high enantioselection, culminating in a practical asym. synthesis of the (3R,5S) isomer (III) of the antihyperlipoproteinemic agent fluvastatin is described. All four 3,5-dihydroxy-6(E)-heptenoate stereoisomers were prepd. in enantiopure form starting from II, utilizing selective redn. and oxidn. methods. 93957-50-7 which is the cas registry number of some chemical is mentioned. ..