Detail of "94-12-2"

CAS Number:
94-12-2
Name:
Benzoic acid, 4-amino-,propyl ester
Molecular Structure:
Formula:
C10H13 N O2
Molecular Weight:
179.22
Synonyms:
Benzoicacid, p-amino-, propyl ester (7CI,8CI); Propesin (6CI);4-(Propoxycarbonyl)aniline; Keloform P; NSC 23516; Propaesin; Propazyl;Propesine; Propyl 4-aminobenzoate; Propyl p-aminobenzoate; Propylcain;Raythesin; Risocaine; n-Propyl p-aminobenzoate; p-Aminobenzoic acid, propylester
Melting Point:
75-80 °C
Hazard Symbols:
Risk Codes:
36/37/38
Safety:
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3

RTECS DG3090000

Hazard Note Irritant
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Thermodynamics of aqueous solutions of alkyl p-aminobenzoate: Thermodynamics of aqueous solutions of alkyl p-aminobenzoate. Paruta, Anthony N. (Coll. Pharm., Univ. Rhode Island, Kingston, RI 02881, USA). Drug Dev. Ind. Pharm., 10(3), 453-65 (English) 1984. CODEN: DDIPD8. ISSN: 0363-9045. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 22 The solubilities of a series of alkyl p-aminobenzoates were detd. in water at 3 temps. The solutes were Me [619-45-4], Et [94-09-7], Pr [94-12-2] and Bu p-aminobenzoate [94-25-7] and the temps. were 25°, 33° and 40°. The thermodn. parameters were calcd. in aq. systems. by soly. detns. at these temps. A recurrent non-linear pattern was obtained in the calcd. and exptl. derived thermodn. values of enthalpy, entropy, and free energy. However, an approx. linear relationship of chem. structure and the partial excess free energy for these solutes was found for their aq. solns.

Importance of solute partitioning on the kinetics of drug release from matrix systems: Importance of solute partitioning on the kinetics of drug release from matrix systems.Some chemicals with cas registry numbers like 14309-40-1 and 13110-37-7 are also used. Roseman, T. J.; Yalkowsky, S. H. (Pharm. Res., Upjohn Co., Kalamazoo, Mich., USA). ACS Symp. Ser., 33(Controlled Release Polym. Formulations, Symp., 1976), 33-52 (English) 1976. CODEN: ACSMC8. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The in vitro release rate of Me [619-45-4], Et [94-09-7], Pr [94-12-2], Bu [94-25-7], pentyl [13110-37-7], hexyl [13476-55-6], and heptyl p-aminobenzoate [14309-40-1] from a Silastic 382 matrix, dependent on the partitioning and soly. of the diffusant and expected square root of time profiles from in vitro expts., may lead to zero-order kinetics in vivo. Biol. studies with a vaginal ring contg. 1 and 2% medroxyprogesterone acetate [71-58-9] support this anal. as const. blood levels result even though a square root of time dependence is obsd. in vitro. .