CAS No.94-20-2,CHLORPROPAMIDE Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	94-20-2
Name:	CHLORPROPAMIDE
Article Data:	44

Formula:	C₁₀H₁₃ClN₂O₃S
Molecular Weight:	276.744
Synonyms:	Urea,1-[(p-chlorophenyl)sulfonyl]-3-propyl- (8CI);1-(p-Chlorobenzenesulfonyl)-3-propylurea;1-Propyl-3-(p-chlorobenzenesulfonyl)urea;Adiaben;Asucrol;Catanil;Chloronase;Diabaril;Diabechlor;Diabenal;Diabenese;Diabeneza;Diabet-Pages;Diabetoral;Diabinese;Glisema;Meldian;Melitase;Millinese;N-(p-Chlorobenzenesulfonyl)-N'-propylurea;NSC 44634;NSC 626720;P 607;Stabinol;U 9818;
EINECS:	202-314-5
Density:	1.334 g/cm³
Melting Point:	128 °C
Boiling Point:	302°C (rough estimate)
Solubility:	Insoluble in water
Appearance:	white crystalline powder
Hazard Symbols:	Xn
Risk Codes:	20/21/22-40
Safety:	22-36
PSA:	83.65000
LogP:	3.60050

Synthetic route

: 110-78-1
Propyl isocyanate

: 98-64-6
4-Chlorobenzenesulfonamide

: 94-20-2
chlorpropamide

Conditions

Conditions	Yield
With copper(l) chloride In nitromethane at 20℃; for 2h; Milling;	92%
With boron trifluoride diethyl etherate In diethyl ether Ambient temperature;	67%

: 98-64-6
4-Chlorobenzenesulfonamide

: 14549-38-3
phenyl N-(n-propyl)carbamate

: 94-20-2
chlorpropamide

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile Reflux; Green chemistry;	85%

: 98-64-6
4-Chlorobenzenesulfonamide

: 39078-44-9
S-Methyl N-propyl(thiocarbamate)

: 94-20-2
chlorpropamide

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 110℃; for 4h; Substitution;	75%

: 2-chlorobenzene sulphonamide

: 6948-23-8
(2-hydroxy-ethyl)-carbamic acid propyl ester

: 94-20-2
chlorpropamide

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide	46%

: 96-49-1
[1,3]-dioxolan-2-one

: 98-64-6
4-Chlorobenzenesulfonamide

: 94-20-2
chlorpropamide

Conditions

Conditions	Yield
With propylamine In water; N,N-dimethyl-formamide

: 94-20-2
chlorpropamide

: C10H12(2)HClN2O3S

Conditions

Conditions	Yield
With Kerr's catalyst; deuterium In chlorobenzene at 120℃; for 1h; Reagent/catalyst; Temperature;	96%

: 94-20-2
chlorpropamide

: 407-25-0
trifluoroacetic anhydride

: 98922-57-7
4-Chloro-N-(2,2,2-trifluoro-acetyl)-benzenesulfonamide

Conditions

Conditions	Yield
In chloroform for 1.5h;	94%

: 94-20-2
chlorpropamide

: 108-24-7
acetic anhydride

A: 5331-48-6
n-propylacetamide

B: 55379-05-0
N-((4-chlorophenyl)sulfonyl)acetamide

Conditions

Conditions	Yield
With pyridine for 0.0833333h;	A 27% B 83%

...Expand

: 94-20-2
chlorpropamide

: N,N'-Bis-(4-chlorphenylsulfonyl)-N''-n-propylguanidin

Conditions

Conditions	Yield
With pyridine; p-toluenesulfonyl chloride Heating;	81%

: 94-20-2
chlorpropamide

: 1600-27-7
mercury(II) diacetate

: mercury bis{N-((propylamino)carbonyl)-4-chlorobenzenesulfonamide}

Conditions

Conditions	Yield
With KOH In ethanol byproducts: CH3COO(1-), H2O; addn. of suspension of Hg(CH3CO2)2 in ethanol to soln. of ligand and KOH, mixt.stirred for 20 min; pptn. on cooling to -10°C, filtered, washed (EtOH, Et2O), dried in vac., elem. anal.;	70%

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Chemistry

IUPAC Name: Chloropropamide
The MF of Chlorpropamide (CAS NO.94-20-2) is C₁₀H₁₃ClN₂O₃S.

The MW of Chlorpropamide (CAS NO.94-20-2) is 276.74.
Synonyms of Chlorpropamide (CAS NO.94-20-2): 1-(4-chlorophenyl)sulfonyl-3-propyl-urea ; 4-Chlor-N-(propylcarbamoyl)benzolsulfonamid ; Benzenesulfonamide, 4-chloro-N-((propylamino)carbonyl)- ; Oradian
Appearance: white crystalline powder
Stability: Stable. Combustible
Index of Refraction: 1.552
EINECS: 202-314-5
Density: 1.334 g/ml
Melting Point: 128 °C
Merck: 2186

Uses

Chlorpropamide (CAS NO.94-20-2) is sulfonylurea oral hypoglycemic agents which mainly selectively act on the pancreatic islet-β-cells, promoting insulin secretion.Chlorpropamide has a relatively large side-effects, so the using of the drug are decreasing trend.

Production

Chlorobenzene sulfonamide reacts with chlorobenzene sulfonyl amide,generating C urea sodium salt. Then hydrochloric acid, refined to derive. Another method is based on chlorobenzene sulfonamide, isopropyl isocyanate, triethylamine as raw materials.

Toxicity Data With Reference

1.	sce-mus-orl 177 mg/kg	MUREAV Mutation Research. 77 (1980),349.
2.	sce-ham-ipr 7100 µg/kg	MUREAV Mutation Research. 77 (1980),349.
3.	orl-wmn TDLo:25 mg/kg/5D-I:BLD	DICPBB Drug Intelligence and Clinical Pharmacy. 18 (1984),981.
4.	orl-wmn TDLo:300 mg/kg:CNS	CTOXAO Clinical Toxicology. 11 (1977),13.
5.	orl-man TDLo:83 mg/kg/25D-I:GIT	AJGAAR American Journal of Gastroenterology. 80 (1985),381.
6.	orl-rat LD50:2150 mg/kg	FATOAO Farmakologiya i Toksikologiya (Moscow). 25 (1962),93.
7.	ipr-rat LD50:580 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),185.
8.	ivn-rat LD50:590 mg/kg	PMDCAY Progress in Medical Chemistry. 1 (1961),187.
9.	orl-mus LD50:1546 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 153 (1965),379.
10.	ivn-mus LD50:500 mg/kg	PMDCAY Progress in Medical Chemistry. 1 (1961),187.

Consensus Reports

NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-45 ,1978. . EPA Genetic Toxicology Program.

Safety Profile

Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: hemolysis with or without anemia, ulceration or bleeding from large intestine, cholestatic jaundice. Human teratogenic effects by ingestion: fetal death. Human reproductive effects by ingestion and possibly other routes: stillbirth, reduced viability and abnormal characteristics of newborn at birth. An experimental teratogen. Experimental reproductive effects. Mutation data reported. An antidiabetic agent. When heated to decomposition it emits very toxic fumes of Cl⁻, NO_x, and SO_x.Safety information of Chlorpropamide (CAS NO.94-20-2):
Hazard Codes Harmful Xn
Risk Statements
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
40 Limited evidence of a carcinogenic effect
Safety Statements
22 Do not breathe dust
36 Wear suitable protective clothing
WGK Germany 3
RTECS YS6650000

Specification

A halogenated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P₂O₅ or SOCl₂ generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NO_x).