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Basic Information
| CAS No.: | 94-41-7 |
|---|---|
| Name: | CHALCONE |
| Article Data: | 474 |
| Molecular Structure: | |
|
|
|
| Formula: | C15H12O |
| Molecular Weight: | 208.26 |
| Synonyms: | Cinnamophenone;NSC 26612;NSC 4523;Phenyl 2-phenylvinyl ketone;Phenyl styryl ketone;Styryl phenyl ketone;a-Benzylideneacetophenone;b-Benzoylstyrene;b-Phenylacrylophenone;1-Phenyl-2-benzoylethylene;2-Benzalacetophenone;2-Benzylideneacetophenone;Chalcone(8CI);1,3-Diphenyl-1-propen-3-one;1,3-Diphenylpropen-3-one;1-Benzoyl-2-phenylethene;Benzylidenecetophenone; |
| EINECS: | 202-330-2 |
| Density: | 1.097 g/cm3 |
| Melting Point: | 55-59 °C |
| Boiling Point: | 346.61 °C at 760 mmHg |
| Flash Point: | 150.062 °C |
| Appearance: | light yellow powder |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 22-36/37 |
| Safety: | 22-36/37/39-45 |
| PSA: | 17.07000 |
| LogP: | 3.58270 |
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CHALCONE
Chemistry
Chalcone's Molecular formula: C15H12O
Chalcone's Molar mass: 208.26 g mol-1
Density: 1.071 g/cm3
Melting point: 55–57 °C
Boiling point: 345-348 °C
Other names: Chalcone;Chalkone;Benzylideneacetophenone;Phenyl styryl ketone
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
Chalcone's Molar mass: 208.26 g mol-1
Density: 1.071 g/cm3
Melting point: 55–57 °C
Boiling point: 345-348 °C
Other names: Chalcone;Chalkone;Benzylideneacetophenone;Phenyl styryl ketone
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
Uses
Chalcones show antibacterial, antifungal, antitumor and anti-inflammatory properties.
Some chalcones demonstrated the ability to block voltage-dependent potassium channels.
Chalcones are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities.
Chalcones are also intermediates in the Auwers synthesis of flavones.
Some chalcones demonstrated the ability to block voltage-dependent potassium channels.
Chalcones are also intermediates in the biosynthesis of flavonoids, which are substances widespread in plants and with an array of biological activities.
Chalcones are also intermediates in the Auwers synthesis of flavones.
Production
Chalcones can be prepared by an aldol condensation between a benzaldehyde and an acetophenone in the presence of sodium hydroxide as a catalyst.
Toxicity Data With Reference
| 1. | ivn-mus LD50:56 mg/kg | CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#04476 . |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Poison by intravenous route. See also KETONES. When heated to decomposition it emits acrid smoke and irritating fumes.
Standards and Recommendations
DOT Classification: 3; Label: Flammable Liquid