Detail of "94-41-7"

Reference

Antioxidants

Antioxidants. (Canon K. K., Japan). Jpn. Kokai Tokkyo Koho JP 58138776 A2 17 Aug 1983 Showa, 5 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C09K015-32. ICA: C08F026-06; C09K009-00; G02F001-17; G03C001-06. APPLICATION: JP 82-22408 15 Feb 1982.There are some reagents with their cas registry numbers 61445-93-0 and 57609-72-0 are used in this study. DOCUMENT TYPE: Patent CA Section: 39 (Synthetic Elastomers and Natural Rubber) Section cross-reference(s): 28 Antioxidants are composed of pyrazoline derivs. having an oxidn. potential ￡1.0 V. The antioxidants exhibit excellent effect against the oxidn. of org. materials. Thus, NaOH 21.8 g dissolved in a mixt. of water 200 mL and EtOH 100 mL reacted with benzaldehyde [100-52-7] 46 g and acetophenone [98-86-2] 52 g to obtain 1,3-diphenyl-2-propen-1-one [94-41-7] (m.p. 55-56°), 30 g of which and 15.6 g of phenylhydrazine [100-63-0] were reacted to obtain antioxidant [742-01-8] (m.p. 135-136°), 2 g of which was added to a compn. contg. natural rubber (smoked sheet) 100, carbon black 40, Zn oxide 5, stearic acid 2, rosin 5, cyclohexylbenzothiazolesulfenamide 0.5, and S 2.5 g to obtain a vulcanized black rubber. Testing the vulcanized black rubber confirmed that the antioxidant showed excellent activity. .

Differential induction of cytosolic epoxide hydrolase, microsomal epoxide hydrolase, and glutathione S-transferase activities

Differential induction of cytosolic epoxide hydrolase, microsomal epoxide hydrolase, and glutathione S-transferase activities. Hammock, Bruce D.; Ota, Kenji (Dep. Entomol.Several substances are used for example 117-81-7 and 1434-54-4 which are their cas registry numbers., Univ. California, Davis, CA 95616, USA). Toxicol. Appl. Pharmacol., 71(2), 254-65 (English) 1983. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Three major enzyme systems metabolized epoxidized xenobiotics in vertebrate tissues; these enzyme systems can be differentially induced. The cytosolic epoxide hydrolase [9048-63-9] activity was routinely monitored with trans-b-ethylstyrene oxide [69140-50-7], the microsomal epoxide hydrolase activity with benzo[a]pyrene 4,5-oxide [37574-47-3], and the glutathione S-transferase [50812-37-8] activity with 2,4-dichloronitrobenzene [611-06-3]. Commonly used inducers of microsomal mixed-function oxidase [9040-60-2], microsomal epoxide hydrolase, and cytosolic glutathione S-transferase activities failed to cause significant induction of the cytosolic epoxide hydrolase while leading to the expected induction of the other epoxide-metabolizing enzymes. The compds. tested by i.p. injection into male mice included phenobarbital [50-06-6], 3-methylcholanthrene [56-49-5], Arochlor 1254 [11097-69-1], trans- [103-30-0] and cis-stilbene oxide [1689-71-0], pregnenolone-16a-carbonitrile [1434-54-4], chalcone [94-41-7], and 4-bromochalcone [1774-66-9]. To det. if there were strain, sex, or species differences, the enzymes were monitored in male C57BL/6 mice, female Swiss-Webster mice, and male Sprague-Dawley rats following i.p. injection of phenobarbital, 3-methylcholanthrene, and(or) pregnenolone-16a-carbonitrile. The time-dependence of enzyme induction was followed in Sprague-Dawley rats following trans-stilbene oxide administration. Male Swiss-Webster mice were addnl. exposed to dietary a-naphthoflavone [604-59-1] and 2(3)-tert-butyl-4-hydroxyanisole [25013-16-5] while male Sprague-Dawley rats were fed 2,6-di-tert-butyl-4-methylphenol [128-37-0]. In no case was significant induction of cytosolic epoxide hydrolase activity obsd. Dietary di(2-ethylhexyl) phthalate [117-81-7], 2-ethyl-1-hexanol [104-76-7], and clofibrate [637-07-0] were potent inducers of the cytosolic epoxide hydrolase in male Swiss-Webster mice while probucol [23288-49-5] (a nonperoxisome-proliferating hypolipidemic drug) failed to cause significant induction. Data from isoelec. focusing expts. and other data are consistent with the epoxide hydrolase activities induced by 2-ethyl-1-hexanol [104-76-7] and clofibrate being due to the same protein that is present in control animals. The lack of induction of the cytosolic epoxide hydrolase by a variety of compds. which were selected to demonstrate induction of other xenobiotic-metabolizing enzymes may indicate that the cytosolic epoxide hydrolase has a constitutive role whereas its induction by clofibrate could be related to some of the pharmacol. and(or) carcinogenic actions of this drug. .