Detail of "94-63-3"

Reference

Effects of organophosphorus compounds and PAM on cholinesterase activity in rat tissues

Effects of organophosphorus compounds and PAM on cholinesterase activity in rat tissues. Yamanaka, Sumie; Nishimura, Masao (Dep. Hyg., Tokyo Dent. Coll., Chiba, Japan). Nippon Eiseigaku Zasshi, 39(5), 795-806 (Japanese) 1984. CODEN: NEZAAQ. ISSN: 0021-5082. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects of 3 organophosphorus compds. (OPC) and PAM [94-63-3] on cholinesterase (ChE) [9001-08-5] activity were studied in rats. Toxic signs appeared in the respiratory function of rats immediately after the administration of dichlorvos [62-73-7], and disappeared rapidly. In the case of rats administered fenitrothion [122-14-5] or pyridafenthion (I) [119-12-0], serious toxic signs such as salivation, dyspnea, lacrimation, and tremors appeared, and these signs continued for several days. ChE activity in rat tissues administered OPC were recovered after the toxic signs disappeared. There was a clear relation between the inhibition levels of tissue ChE and the appearance of toxic signs in rats administered 3 OPC. Salivary secretion was induced by OPC when the activity of ChE in salivary glands was inhibited by >50% of normal activity. The half-time (r1/2) for recovery of tissue ChE activity in rats was different by tissues. But the r1/2 for recovery of serum and liver ChE activity was the same as the ~20 h for 3 OPC. The r1/2 for recovery of erythrocyte ChE of rats treated with fenitrothion was 410 h. Atropine was unable to reactivate tissue ChE activity inhibited by the 3 OPC. The antidote PAM was capable of reactivating ChE activity in only serum and erythrocytes of rats administered I, but it couldn't reactivate ChE activity in brain, liver, kidneys, lung, and salivary glands for I, nor ChE activity in any tissues for dichlorvos and fenitrothion. Thus, each ChE in rat tissues has many differences in the speed of spontaneous recovery and the reactivating effect of PAM following poisoning with OPC.

Document searching for the case of acute poisoning by organophosphorus pesticides using JOIS

Document searching for the case of acute poisoning by organophosphorus pesticides using JOIS. Futagami, Kojiro; Asakura, Hajime; Fukagawa, Mitsuro; Fujii, Toshiyuki; Horioka, Masayoshi (Fac. Med., Kyushu Univ., Higashi 812, Japan). Joho Kanri, 28(10), 873-84 (Japanese) 1986. CODEN: JOKAAB. ISSN: 0021-7298. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 20 The JICST (Japan Information Center of Science and Technol.) Online Information System (JOIS) was used to search for case reports of acute poisoning by so-called low-toxicity organophosphorus pesticides. This searching was intended to attempt to discuss the efficacy of a cholinesterase reactivator PAM (pralixodime) [94-63-3] in the clin. treatment of such poisoning. Three data bases, EMBASE, TOXLINE, and MEDLINE, were selected for searching, and the search terms representing organophosphorus pesticides, cholinesterase reactivators, and clin. cases were chosen for each database. From these 3 data bases, 35, 28 and 17 relevant documents were found, resp., but 17 from the MEDLINE were fully included in 28 from the TOXLINE. Thirteen documents were overlapped between EMBASE and TOXLINE, so 50 independent documents were identified as relevant in this search. A significant fraction of the relevant documents would not be found if the search terms for clin. cases were limited to CASE REPORT or :CASE and REPORT only and the addn. of the terms such as HUMAN was necessary for a comprehensive search.