CAS No.943-17-9,Etilefrine hydrochloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	943-17-9
Name:	Etilefrine hydrochloride

Formula:	C₁₀H₁₆ClNO₂
Molecular Weight:	217.696
Synonyms:	Benzenemethanol,a-[(ethylamino)methyl]-3-hydroxy-,hydrochloride (9CI);Benzyl alcohol, a-[(ethylamino)methyl]-m-hydroxy-, hydrochloride(6CI,8CI);Apocretin;Circupon;Effontil;Effortilvet;Ethyl adrianol;Ethylephrine hydrochloride;Eti-Puren;Funasol;Kertasin;Phetanol;Pulsamin;Tonus-Forte;Updormin;dl-1-(3-Hydroxyphenyl)-1-hydroxy-2-ethylaminoethane hydrochloride;dl-Ethylphenylephrine hydrochloride;
EINECS:	213-398-8
Density:	1.127g/cm3
Melting Point:	122 °C
Boiling Point:	351.7 °C at 760 mmHg
Flash Point:	155.5 °C
Appearance:	white
PSA:	57.07000
LogP:	-2.98710

Synthetic route

: 943-17-9
Apocretin

: (+)-<(R)-Tetrahydrofurfuryl-(1S)-campher-sulfonat>

: N-<(R)-Tetrahydrofurfuryl>-(+/-)-etilefrin

Conditions

Conditions	Yield
With sodium hydrogencarbonate; sodium iodide In N,N-dimethyl-formamide at 100℃; for 10h;	94%

: 943-17-9
Apocretin

: 119610-62-7
N-Ethyl-2-chloro-2-(3-hydroxyphenyl)ethylamine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In benzene at 40 - 45℃; for 1h;	46%

: 943-17-9
Apocretin

: 119610-65-0
1-(3-Hydroxyphenyl)-2-ethylaminoethylthiophosphoric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 46 percent / SOCl2 / benzene / 1 h / 40 - 45 °C 2: 18 percent / Na3SPO3*12H2O / H2O / 4 h View Scheme

: 943-17-9
Apocretin

: 119610-63-8
1-(3-Hydroxyphenyl)-2-ethylaminoethylthiosulfuric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 46 percent / SOCl2 / benzene / 1 h / 40 - 45 °C 2: 57 percent / Na2S2O3*5H2O / H2O / 1.) 40 deg C, 3 h, 2.) 60 deg C, 4 h View Scheme

: copper(II) choride dihydrate

: 943-17-9
Apocretin

: 307975-81-1
Cu(α-[(etylamino)methyl]-3-hydroxy-benzenemethanol)2

Conditions

Conditions	Yield
In water at excess of ligand (1:2-1:10) and pH=10.5;

: 67-56-1
methanol

: copper(II) choride dihydrate

: 943-17-9
Apocretin

: 307975-83-3
Cu2(α-[(etylamino)methyl]-3-hydroxy-benzenemethanol)2Cl2

Conditions

Conditions	Yield
With NaOH In methanol ligand dissolved in MeOH, added methanolic solns. of CuCl2*2H2O and NaOHat molar ratio Cu-ligand-NaOH=1:2:2, allowed to stand for 3 d; filtered, washed with MeOH, dried over P2O5, elem. anal.;

...Expand

: 67-56-1
methanol

: copper(II) choride dihydrate

: 943-17-9
Apocretin

: Cu(α-[(ethylamino)methyl]-3-hydroxy-benzenemethanol)2*2MeOH

Conditions

Conditions	Yield
With NaOH In methanol ligand dissolved in MeOH, added methanolic solns. of CuCl2*2H2O and NaOHat molar ratio Cu-ligand-NaOH=1:10:20, allowed to stand for 4 mo; filtered, washed, dried over P2O5, elem. anal.;

...Expand

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119610-65-0

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Chemistry

Product Name: Etilefrine hydrochloride (CAS NO.943-17-9)

MF: C₁₀H₁₆ClNO₂
MW: 217.69
Melting Point: 122 °C
EINECS: 213-398-8
Flash Point: 155.5 °C
Enthalpy of Vaporization: 62.94 kJ/mol
Boiling Point: 351.7 °C at 760 mmHg
Vapour Pressure: 1.5E-05 mmHg at 25°C
H-Bond Donor: 4
H-Bond Acceptor: 3
Structure Descriptors of Etilefrine hydrochloride (CAS NO.943-17-9):
IUPAC Name: 3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride
Canonical SMILES: CCNCC(C1=CC(=CC=C1)O)O.Cl
InChI: InChI=1S/C10H15NO2.ClH/c1-2-11-7-10(13)8-4-3-5-9(12)6-8;/h3-6,10-13H,2,7H2,1H3;1H
InChIKey: KTNROWWHOBZQGK-UHFFFAOYSA-N
Classification Code: Drug / Therapeutic Agent

Toxicity Data With Reference

1.	orl-rat LDLo:187 mg/kg	DRFUD4 Drugs of the Future. 4 (1979),413.
2.	ivn-rat LDLo:5 mg/kg	DRFUD4 Drugs of the Future. 4 (1979),413.
3.	orl-mus LDLo:345 mg/kg	DRFUD4 Drugs of the Future. 4 (1979),413.
4.	ivn-mus LDLo:11 mg/kg	DRFUD4 Drugs of the Future. 4 (1979),413.

Safety Profile

Poison by ingestion and intravenous routes. When heated to decomposition it emits very toxic fumes of HCl and NO_x. See also ALCOHOL, DENATURED; ALCOHOLS, C6-12; ALCOHOLS, C9-11; ALCOHOLS, C12-13, ETHOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED; ALCOHOLS, C12-16, ETHOXYLATED; ALCOHOLS, C14-15, ETHOXYLATED; ALCOHOLS, C16-18, ETHOXYLATED; ALCOHOLS, C8-10, ETHOXYLATED PROPOXYLATED; ALCOHOLS, C12-15, ETHOXYLATED PROPOXYLATED; ALCOHOLS, N.O.S.
Safety information of Etilefrine hydrochloride (CAS NO.943-17-9):
RTECS DO5618000

Specification

Etilefrine hydrochloride , its CAS NO. is 943-17-9, the synonyms are alpha.-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride ; 3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride ; Effortil ; Efortil ; Etilefrin dl-form hydrochloride ; ( -)-Ethylphenylephrine hydrochloride ; ( -)-N-Ethylnorphenylephrine hydrochloride ; 1-(3-Hydroxyphenyl)-2-ethylaminoethanol hydrochloride .