Detail of "944-73-0"

CAS Number:
944-73-0
Name:
1H-Purine-2,6,8(3H)-trione,7,9-dihydro-1,3-dimethyl-
Superlist Name:
1,3-Dimethyluric acid
Molecular Structure:
Formula:
C₇H₈N₄O₃
Molecular Weight:
196.16
Synonyms:
Uric acid,1,3-dimethyl- (6CI,7CI,8CI);NSC 95854;Oxytheophylline;1,3-Dimethyl-7,9-dihydropurine-2,6,8-trione;
EINECS:
213-410-1
Density:
1.63 g/cm³
Melting Point:
≥300 °C(lit.)
Boiling Point:
520.2 °C at 760 mmHg
Flash Point:
268.4 °C
Safety:
24/25 Details

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Metabolism and pharmacodynamics of theophylline: Metabolism and pharmacodynamics of theophylline. Miech, R. P.; Lohman, S. M. (Div. Biol. Med. Sci., Brown Univ., Providence, R. I., USA). New Dir. Asthma, [Int. Symp.], Meeting Date 1974, 377-90. Edited by: Stein, Myron. Am. Coll. Chest Physicians: Park Ridge, Ill. (English) 1975. CODEN: 36FDAH. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) In rat tissue slice expts., liver was the only tissue capable of metabolizing theophylline (I) [58-55-9]. I was oxidized to 1,3-dimethyluric acid [944-73-0] and demethylated to 1-methylxanthine [708-79-2]. Pharmacodynamic anal. of adenylate cyclase and phosphodiesterase interaction with I are discussed.

Binding of theophylline and its metabolites to human plasma proteins: Binding of theophylline and its metabolites to human plasma proteins. Gundert-Remy, Ursula; Hildebrandt, Ruth (Abt. Klin. Pharmakol., Med. Universitaetsklin., Heidelberg, Fed. Rep. Ger.). Br. J. Clin. Pharmacol., 16(5), 573-4 (English) 1983. CODEN: BCPHBM. ISSN: 0306-5251. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The binding of theophylline (I) [58-55-9], and its metabolites 1-methyluric acid (1-MU) [708-79-2], 1,3-dimethyluric acid (1,3-DMU) [944-73-0], and 3-methylxanthine (3-MX) [1076-22-8] to human plasma proteins was studied in vitro. The binding of I and 1,3-DMU was concn. dependent with ~35% and ~71% bound at 20 mg/L, resp. and ~44% and ~74% bound at 2. 708-79-2 and 1076-22-8 which are cas registry numbers of substances are two of reagents here.5 mg/L, resp. The binding of I and 1,3-DMU was significantly lower in the presence of these drugs. 1-MU displayed no binding to plasma proteins and the protein binding of 3-MX was low, showed no concn.-dependency and was not influenced by the presence of the other compds. .