Detail of "94528-08-2"

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Anticonvulsant activity of the nipecotic acid ester, (±)-m-nitrophenyl-3-piperidinecarboxylate

Anticonvulsant activity of the nipecotic acid ester, (±)-m-nitrophenyl-3-piperidinecarboxylate. Hinko, Christine N.; Seibert, Karen; Crider, A. M. (Dep. Pharmacol., Univ. Toledo, Toledo, OH 43606, USA). Neuropharmacology, 23(9), 1009-14 (English) 1984. CODEN: NEPHBW. ISSN: 0028-3908. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of the title compd. (I) [93801-23-1] on convulsions induced by chem. which interfere with GABA-mediated neurotransmission were studied in the mouse, with I being administered by s.c. injection 30, 60, or 90 min prior to challenge with bicuculline. I protected against convulsions induced by bicuculline with ED50 values for clonic and tonic convulsions of 157.8 and 138.8 mg/kg, resp., at the time of peak effect of 60 min and I abolished both the clonic and tonic components of isoniazid convulsions with resp. ED50 values of 255.3 and 76.7 mg/kg at 1 h. Picrotoxin and pentylenetetrazol-induced seizures were also blocked with corresponding ED50 values for clonic convulsions of 224.9 and 235.Several substances are used for example 94528-08-2 which is its cas registry number.9 mg/kg at 1 h. No serious side effects were obsd. during the 90 min period after the administration of I in doses up to 600 mg/kg. .