Reference

Determination of Residual Organic Solvents in Salmeterol Xinafoate by Capillary Gas Chromatography

Determination of Residual Organic Solvents in Salmeterol Xinafoate by Capillary Gas Chromatography. Zhu, Wei; Wang, Yan; Huang, Yueqin; Dai, Jian (Shanghai Institute for Drug Control, Shanghai 200233, Peop. Rep. China). Zhongguo Yiyao Gongye Zazhi, 33(5), 237-238 (Chinese) 2002 Zhongguo Yiyao Gongye Zazhi Bianjibu. CODEN: ZYGZEA. ISSN: 1001-8255. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A simple capillary gas chromatog. method for the detn. of residual ethoxyethane, EtOH, iso-PrOH, EtOAc, THF, CHCl3, and toluene in Salmeterol xinafoate was presented. The linearities were fairly good, limit of detection was 0.074-0. 94749-08-3 and 60-29-7 are also in the experiment.63 ng, and recovery was 89.1-102.7% with relative std. deviation of 2.9-5.2%. .

Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells

All Rights Reserved.Some chemicals with cas registry numbers like 51-45-6 and 94749-08-3 are also used. Effects of salmeterol xinafoate and fluticasone propionate on immunological activation of human cultured mast cells. Akabane, Hirotomo; Murata, Masayuki; Kubota, Masafumi; Takashima, Eiji; Tanaka, Hiroyuki; Inagaki, Naoki; Horiba, Michiaki; Nagai, Hiroichi (Department of Pharmacology, Gifu Pharmaceutical University, Gifu, Japan). Allergology International, 55(4), 387-393 (English) 2006 Japanese Society of Allergology. CODEN: ALINFR. ISSN: 1323-8930. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Background: The clin. efficacy of combination therapy comprising a long acting b2-agonist (LABA) and corticosteroid is widely recognized for the treatment of adult asthma. Here we examine the effect of salmeterol xinafoate (SX) and fluticasone propionate (FP) alone and in combination on the immunol. activation of human cultured mast cells (HCMC) in vitro. Methods: HCMC were passively sensitized with IgE antibody and then activated by challenging with anti-IgE antibody. The effect of drugs on the activation of mast cells was examd. by measuring the amt. of released chem. mediators (histamine, leukotrienes (LT) and prostaglandin D2 (PGD2)) and granulocyte macrophage colony stimulating factor (GM-CSF). Results: The release of each chem. mediator was inhibited by 10-9-10-8M SX but not by 10-10-10-7M FP. The prodn. of GM-CSF was inhibited by a concn. of 10-8M in both drugs and the inhibition was augmented by combined treatment with 10-11M of each drug. Conclusions: The immunol. release of chem. mediators (histamine, LT, PGD2) from HCMC was inhibited by SX but not by FP. SX and FP inhibited the prodn. of GM-CSF by HCMC and both drug showed synergistic inhibition in the prodn. of GM-CSF. .