Reference

Improvement of synthesis method for the solid-phase peptide coupling reagent HBTU

Improvement of synthesis method for the solid-phase peptide coupling reagent HBTU. Pan, Heping; Chen, Zhengying (Institute Basic Medical Science, AMMS, Beijing 100850, Peop. Rep. China). Huaxue Shiji, 18(6), 362-363 (Chinese) 1996 Huagongbu Huaxue Shiji Keji Qingbao Zhongxinzhan. CODEN: HUSHDR.Several substances with their cas registry numbers 13829-06-6 and 94790-37-1 may be metioned in this study. ISSN: 0258-3283. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 34 2-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HBTU) was prepd. in 3 steps starting from reaction of (Me2N)2CO with oxalyl chloride. .

Hapten-carrier conjugates, and their preparation, for use in drug-abuse therapy

Hapten-carrier conjugates, and their preparation, for use in drug-abuse therapy. Swain, Philip A.; Schad, Victoria C.; Greenstein, Julia L.; Exley, Mark A.; Fox, Barbara S.; Powers, Stephen P.; Gefter, Malcolm L.; Briner, Thomas J. (Immulogic Pharmaceutical Corporation, USA). PCT Int. Appl. WO 9630049 A2 3 Oct 1996, 92 pp. DESIGNATED STATES: W: AM, AT, AU, BB, BG, BR, BY, CA, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MD, MG, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K047-48. APPLICATION: WO 1996-US4189 27 Mar 1996. PRIORITY: US 1995-414971 30 Mar 1995; US 1995-563673 28 Nov 1995. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 15, 31 Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic compn., are disclosed. Methods of prepg. 94790-37-1 and 61585-22-6 which are cas registry numbers of chemicals are mentioned. said conjugates and therapeutic compns. are also disclosed. Where the hapten is a drug of abuse, a therapeutic compn. contg. the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic compn. is suitable for co-therapy with other conventional drugs. Data are presented which demonstrate that cocaine-carrier conjugates can be synthesized which induce high-titer, cocaine-specific antibody responses. .