Detail of "948-60-7"

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CAS Number:
948-60-7
Name:
6-Pteridinecarboxylicacid, 2-amino-3,4-dihydro-4-oxo-
Superlist Name:
Pterin-6-carboxylic acid
Molecular Structure:
Formula:
C₇H₅ N₅ O₃
Molecular Weight:
207.1463
Synonyms:
6-Pteridinecarboxylicacid, 2-amino-1,4-dihydro-4-oxo- (8CI,9CI);6-Pteridinecarboxylic acid,2-amino-4-hydroxy- (6CI);6-Carboxypterin;NSC 96893;Pterin-6-carboxylic acid;Ranachrome 5;
EINECS:
213-435-8
Density:
2.16 g/cm³
Boiling Point:
608.7 °C at 760 mmHg
Flash Point:
322 °C
Safety:
22-24/25 Details

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Determination of folic acid in multivitamin preparations and premixes: Determination of folic acid in multivitamin preparations and premixes. Moszczynski, Piotr; Stasiak, Anna (Inst. Biochem. Technol., Politech. Lodzka, Lodz, Pol.). Zesz. Nauk. - Politech. Lodz., Technol. Chem. Spozyw., (No. 38), 119-28 (Polish) 1984. CODEN: ZPLSDI. ISSN: 0209-0600. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) To detn. folic acid (I) [59-30-3] in Polfamix L, a 1-g sample contg. 150 g I was dissolved in 10 mL 0.05M NaOH and 15 mL 0.05M HCl, and the soln. purified on a column packed with Florisil or Fuller's earth. I was eluted with boiling 4% Na2B4O7 and oxidized at pH 3 with 4% KMnO4 to 2-amino-4-hydroxypteridine-6-carboxylic acid [948-60-7], whose fluorescence was excited at pH 4-4.5 at 365 nm and measured at 470 nm.

Chromatographic assays for folic acid: Chromatographic assays for folic acid. Reif, Van D.; Reamer, Jeanne T.; Grady, Lee T. (Drug Res. Test. Lab., United States Pharmacopeia, Rockville, Md., USA). J. Pharm. Sci., 66(8), 1112-16 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Thin-layer chromatog. and high-pressure liq. chromatog. (HPLC) assays for folic acid (I) [59-30-3] were developed. In the thin-layer procedure, the I band was extd. from the silica gel after development and detd. spectrophotometrically by an oxidn. and Bratton-Marshall sequence. A column packed with octadecylsilane chem. bonded to microparticulate silica gel was used for the HPLC assay. Potentiometric detn. of water in I samples was necessary to obtain accurate purity values. In a comparison of 4 assay methods, a direct colorimetric method gave precise, but unspecific, results, while the USP XIX colorimetric method lacked both precision and specificity. The 2 chromatog. methods were both precise and specific and gave the same assay results. Both methods sepd. p-aminobenzoic acid [150-13-0], N-(p-aminobenzoyl)-L-glutamic acid [4271-30-1], 2-amino-1,4-dihydro-4-oxo-6-pteridinecarboxylic acid [948-60-7], 2-amino-4(1H)-pteridinone [2236-60-4], and several unidentified impurities from I.