Detail of "94841-17-5"

CAS Number:
94841-17-5
Name:
Spirapril hydrochloride
Molecular Structure:
Formula:
C₂₂H₃₀N₂O₅S₂.HCl
Molecular Weight:
503.07
Synonyms:
(2S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,9-dithia-3-azaspiro[4.4]nonane-2-carboxylic acid hydrochloride;(8S-(7(R*(R*)),8R*))-7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,4-Dithia-7-azaspiro[4.4]nonane-8-carboxylic acid monohydrochloride;Renormax;Renpress;Sandopril;TI 211-950;
Melting Point:
192-194°C
Boiling Point:
697.8 °C at 760 mmHg
Flash Point:
375.8 °C
Appearance:
White Solid

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Simultaneous determination of Spirapril and Spiraprilat in plasma by capillary gas chromatography-mass spectrometry: Simultaneous determination of Spirapril and Spiraprilat in plasma by capillary gas chromatography-mass spectrometry. Schurer, Michael; Amschler, Stefan; Schulz, Hans-Ulrich; Schafer, Harald F. (LAFAA Laboratory for Contract Research in Clinical Pharmacology and Biopharmaceutical Analytics GmbH, Bad Schwartau, Germany). Arzneimittel-Forschung, 53(5), 307-313 (English) 2003 Editio Cantor Verlag. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A specific, sensitive, and precise method for the simultaneous detn. of Spirapril (CAS 94841-17-5) and Spiraprilat (CAS 83602-05-5) in human plasma is described. The method involves the use of Enalapril as internal std., solid-phase extn., derivatization, and capillary gas chromatog. with mass sensitive detection. The working range is from 2.5 to 500 mg/L for Spirapril and Spiraprilat, resp. Data demonstrating the precision and accuracy of the anal. method are given. Moreover, data concerning freeze-thaw stability, long-term stability of frozen samples, short-term stability of thawed samples, and stability of the exts. in the autosampler are given.