Detail of "95-16-9"

MSDS Download
CAS Number:
95-16-9
Name:
Benzothiazole
Molecular Structure:
Formula:
C₇H₅NS
Molecular Weight:
135.19
Deleted CAS:
128366-28-9
Synonyms:
1-Thia-3-azaindene;Benzo[d]thiazole;Benzosulfonazole;NSC 8040;Vangard BT;1,3-Benzothiazole;
EINECS:
202-396-2
Density:
1.272 g/cm³
Melting Point:
2 °C(lit.)
Boiling Point:
227 °C at 760 mmHg
Flash Point:
96.6 °C
Solubility:
slightly soluble in water
Appearance:
yellow liquid with an unpleasant odour
Hazard Symbols:
Xn
Risk Codes:
20/21/22
Safety:
23-26-36/37 Details
Transport Information:
UN 2810 6.1/PG 3

Famous Chemical Enterprises

Livzon
Total
Shell
Dupont
Exxonmobil
Akzonobel
Basf
Bayer
BP

Reference

Synthesis of polydeuterated benzothiazoles via supercritical deuteration of anilines: Synthesis of polydeuterated benzothiazoles via supercritical deuteration of anilines. Junk, Thomas; Catallo, W. James; Civils, L. Dana (Hazardous Waste Research Center, SVM, Louisiana State University, Baton Rouge, LA 70803, USA). Journal of Labelled Compounds & Radiopharmaceuticals, 39(8), 625-630 (English) 1997 Wiley. CODEN: JLCRD4. ISSN: 0362-4803. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) 2-[2H]Benzothiazole, readily available according to the literature, was obsd. to undergo slow isotope exchange in water. This necessitated development of practical syntheses for benzothiazoles carrying deuterium labels in positions other than 2. [4,5,6,7-2H4]Benzothiazole and 4-[2H3]methyl[5,6,7-2H3]benzothiazole were prepd. in good yields from [2H7]aniline and 2-[2H9]toluidine, which were obtained by novel rapid isotope exchange in supercrit. deuterium oxide.

Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives: Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives.In this experiment, several chemicals are used like 108-30-5 Mylari, Banavara L.; Zembrowski, William J.; Beyer, Thomas A.; Aldinger, Charles E.; Siegel, Todd W. (Cent. Res. Div., Pfizer Inc., Groton, CT 06340, USA). J. Med. There are some commonly used reagents like 108-30-5 in this article. Chem., 35(12), 2155-62 (English) 1992. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 Benzothiazole side chains featured in zopolrestat (I) and its congeners were incorporated into oxophthalazinoneacetic acid replacements, including indazole, pyridazinone, and pyridopyridazinone with a pendant acetic acid moiety. Potent aldose reductase inhibition activity among resulting compds. is as widespread as it is in the earlier zopolrestat series, thus lending further support to our hypothesis that there is a binding site on the aldose reductase enzyme with strong affinity for benzothiazoles. Representative new compds. 1-[(5,7-difluoro-2-benzothiazolyl)methyl]-1H-indazoleacetic acid, [6-[[5-(trifluoromethyl)benzothiazol-2-yl]methyl]-8-oxo-6H-pyrido[2-3-d]p yridazin-5-yl]acetic acid, 3,4-dihydro-4-oxo-5,6-dimethyl-3-[(5,7-difluorobenzothiazol-2-yl)methyl]- 1-pyridazineacetic acid (II), and 3,4-dihydro-4-oxo-5,6-cyclohexano-3-[[5-(trifluoromethyl)benzothiazol-2- yl]methyl]-1-pyridazineacetic acid (III) are potent aldose reductase inhibitors with IC50s of 30, 2.1, 1, and 5.2 nM, resp. The best of these compds., II and III, also inhibit accumulation of sorbitol in rat sciatic nerve in a model of diabetic complications, when administered orally at 10 mg/kg. The inhibition values are 76 and 61%, resp. In addn. to benzothiazole, its surrogates effective in potentiating aldose reductase inhibition activitywere examd. including benzoxazole and aryl[1,2,4]oxadiazole. Structure-activity relations emerging from this program are also discussed. ..

Detail of "95-16-9"

Benzothiazole

Famous Chemical Enterprises

Related products

Other Products

Supplier Location

Business Type

Certificates

Exhibitions

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

CAS No.95-16-9 Benzothiazole

Reference