Detail of "95-44-3"

Reference

An in Vitro Selection System for TNA

An in Vitro Selection System for TNA. Ichida, Justin K.; Zou, Keyong; Horhota, Allen; Yu, Biao; McLaughlin, Larry W.; Szostak, Jack W. (Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA). Journal of the American Chemical Society, 127(9), 2802-2803 (English) 2005 American Chemical Society. CODEN: JACSAT.In this article, certain chemicals are used. One of their cas registry numbers is 95-44-3 ISSN: 0002-7863. DOCUMENT TYPE: Journal CA Section: 6 (General Biochemistry) Section cross-reference(s): 7 (3'-2')-a-L-Threose nucleic acid (TNA) is an unnatural polymer that possesses the rare ability to base-pair with RNA, DNA, and itself. This feature, coupled with its chem. simplicity, makes TNA of interest as a possible progenitor of RNA during the early history of life. To evaluate the functional potential of TNA, the authors have developed a system for the in vitro selection of TNA. The authors identified the Therminator DNA polymerase as a remarkably efficient DNA-dependent TNA polymerase capable of polymg. more than 50 tNTPs. The authors have also developed a method of covalently linking a DNA template to the TNA strand that it encodes, thus obviating the need for a TNA-dependent DNA polymerase during cycles of selection. .