Reference

Omeprazole salts

Omeprazole salts. Brandstrom, Arne Alof (Aktiebolag Haessle, Swed.). Brit. UK Pat. Appl. GB 2137616 A1 10 Oct 1984, 6 pp. (English). (United Kingdom). CODEN: BAXXDU. CLASS: IC: C07D401-12; A61K031-44. APPLICATION: GB 84-5511 2 Mar 1984. PRIORITY: SE 83-1182 4 Mar 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Omeprazole salts (I, An+ = Li+, Na+, K+, Mg2+, Ca2+, Ti4+, N+R14 or H2NC+(NH2)2 where R1 = C1-4 alkyl; n = 1, 2 or 4) are prepd. for treatment of gastrointestinal disorders when cytoprotective and(or) gastric antisecretory effects are desired. The salts are more storage stable than the neutral form.In this article, certain chemicals are used. One of their cas registry numbers is 95510-70-6 Omeprazole Na salt [95510-70-6] was prepd. from the omeprazole and NaOH. A syrup was prepd. contg. the Na salt 1.0, powd. sugar 30.0, saccharin 0.6, glycerol 5.0, flavor 0. 95510-70-6 is also in the experiment.05, EtOH 5.0, sorbic acid 0.5 NaH2PO4 9.0 g and distd. H2O to 100 mL. ..

Development and validation of a RP-HPLC method to quantify omeprazole in delayed release tablets

All Rights Reserved. Development and validation of a RP-HPLC method to quantify omeprazole in delayed release tablets. Murakami, Fabio S.; Cruz, Ariane P.; Pereira, Rafael N.; Valente, Bruno R.; Silva, Marcos A. S. (Laboratorio de Controle de Qualidade, Departamento de Ciencias Farmaceuticas, Universidade Federal de Santa, Catarina, Brazil). Journal of Liquid Chromatography & Related Technologies, 30(1), 113-121 (English) 2007 Taylor & Francis, Inc. CODEN: JLCTFC. ISSN: 1082-6076. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) An anal.There are some reagents with their cas registry numbers 95510-70-6 and 73590-58-6 are used in this study. method using a sensitive high performance liq. chromatog. technique was developed to quantify omeprazole in delayed release tablets. The anal. was carried out using a RP-C18 column with UV-Vis detection at 280 nm. The mobile phase was dild. with phosphate buffer (pH 7.4) and acetonitrile ( vol./vol.) at a flow-rate of 1.5 mL×min-1. The parameters used in the validation process were: linearity, range, quantification limit, accuracy, specificity, and precision. The retention time of omeprazole was about 5 min with sym. peaks. The linearity in the range of 10.0-30.0 mg/mL presented a correlation coeff. of 0.9995. The excipients in the formulation did not interfere with the anal. and the recovery was quant. Results were satisfactory and the method proved to be adequate for quality control of omeprazole delayed release tablets. .