Detail of "956-90-1"

Reference

Stress-induced decreases in the serum concentration of progesterone in the pregnant baboon

Stress-induced decreases in the serum concentration of progesterone in the pregnant baboon. Albrecht, E. D.; Nightingale, M. S.; Townsley, J. D. (Natl. Inst. Child Health Dev., Natl. Inst. Health, Bethesda, Md., USA). J. Endocrinol., 77(3), 425-6 (English) 1978. CODEN: JOENAK. ISSN: 0022-0795. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 13 Pregnant baboons were restrained and bled every 10 min for a period of 90 min; during this period, serum progesterone [57-83-0] concns. fell by 33-66% and at similar rates in nonsedated baboons and in baboons sedated with phencyclidine-HCl [956-90-1] (30 mg, i.m., then 1-1.5 mg/kg/h by i.v. infusion), chlordiazepoxide-HCl [438-41-5] (10 mg/kg, orally, before bleeding), or ketamine-HCl [1867-66-9] (100 mg, i.m., then 3 mg/min by i.v. infusion). During bleeding, serum cortisol [50-23-7] concns. increased in nonsedated and chloridazepoxide-pretreated animals and in one phencyclidine-treated animal, but decreased in 2 of the 3 ketamine-sedated baboons. The decrease in serum progesterone may reflect its reduced formation caused by stress-induced vasoconstriction and assocd. changes in ovarian/placental blood flow.

Anticholinesterase and antiacetylcholine activity of 1-phenylcyclohexylamine derivatives

Anticholinesterase and antiacetylcholine activity of 1-phenylcyclohexylamine derivatives. Kloog, Yoel; Rehavi, Moshe; Maayani, Saul; Sokolovsky, Mordechai (George S. Wise Cent. Life Sci., Tel-Aviv Univ., Tel-Aviv, Israel). Eur. J. Pharmacol., 45(3), 221-7 (English) 1977. CODEN: EJPHAZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The antiacetylcholine and anticholinesterase potencies of 4 1-phenylcyclohexylamine derivs. were estd. by measuring their antagonism to the contractile response of smooth and striated muscles, and their inhibition of acetylcholinesterase [9000-81-1] activity. In addn., their affinities towards the central muscarinic receptor from mouse brain homogenate were detd. by competition expts. in vitro. Relative to atropine, these drugs exerted mild antimuscarinic activity in both isolated smooth muscle and in the competition expts. On the other hand, they were found to exert antinicotinic potencies equal to that of d-tubocurarine in the striated muscle. The concn. of tritriated phencyclidine-HCl (I-HCl) [956-90-1] taken up by mouse brain in vivo could be correlated with its dissocn. consts. from the central muscarinic binding sites, as well as with the Ki values for acetylcholinesterase inhibition, both detd. in vitro. Since these drugs have a similar rigid spatial mol. structure, it is proposed that the variations in the potency of their cholinergic interactions stemmed mainly from the structural changes in the region of the "cationic head".