Reference

Pharmacologic actions of newer beta blocking agents

Pharmacologic actions of newer beta blocking agents. Cohen, Lawrence S.; Vastagh, George F.; Mitchell, Jere H.In this study， 13655-52-2 and 525-66-6 are also used. (Sch. Med., Yale Univ., New Haven, Conn., USA). Res. Anim. Med., [Natl. Conf. Res. Anim. Med.], Meeting Date 1972, Issue DHEW PUBL. (NIH) 72-333, 709-14. Edited by: Harmison, Lowell T. GPO: Washington, D. C. (English) 1973. CODEN: 34CRAU. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) In an open chest canine prepn., the chronotropic and inotropic effects of propranolol [525-66-6], sotalol-HCl [959-24-0], practolol (I) [6673-35-4], and alprenolol [13655-52-2] were studied. I blocked the chronotropic and inotropic responses to isoproterenol most effectively followed closely by propranolol. All 4 agents displayed equiv. intrinsic neg. chronotropic activity. Sotalol had greatest intrinsic neg. chronotropic effect followed by propranolol. A differing chronotropic and inotropic effects of these agents may prove to be significant in the treatment of patients with angina pectoris. .

Beta-adrenergic receptor blocking drugs in spontaneous hypertension

Beta-adrenergic receptor blocking drugs in spontaneous hypertension. Levy, Joseph V. (Sch. Med. Sci., Univ. Pac., San Francisco, Calif.Some commonly used reagents like 6452-71-7 and 6673-35-4 are used in this experiment., USA). Am. J. Med., 61(5), 779-89 (English) 1976. CODEN: AJMEAZ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Of the 11 substances tested, LB-46 (pindolol) [21870-06-4], H93/26 (metoprolol) [37350-58-6] and, to a lesser degree, H56/28 (alprenolol) [13707-88-5] and MJ-1999 (sotalol) [959-24-0] decreased systolic blood pressure in spontaneously hypertensive rats. With the doses used, s.c. and/or oral administration of the other agents either had no effect or increased arterial pressure. The blood pressure lowering effect of pindolol and metoprolol was not seen in age-matched normotensive control rats. This suggest a basic difference between the hypertensive and normotensive rats in regard to .beta.-adrenergic mechanisms that participate in regulating arterial blood pressure. .