Detail of "96-91-3"

Reference

Bioconcentration and metabolism of picric acid (2,4,6-trinitrophenol) and picramic acid (2-amino-4,6-dinitrophenol) in rainbow trout (Salmo gairdneri)

Bioconcentration and metabolism of picric acid (2,4,6-trinitrophenol) and picramic acid (2-amino-4,6-dinitrophenol) in rainbow trout (Salmo gairdneri). Cooper, Keith R.; Burton, Dennis T.; Goodfellow, William L.; Rosenblatt, David H. (Cook Coll., Rutgers, State Univ. New Jersey, New Brunswick, NJ 08903, USA). J. Toxicol. Environ. Health, 14(5-6), 731-47 (English) 1984. CODEN: JTEHD6. ISSN: 0098-4108. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The bioconcn. and metab. of picric (I) [88-89-1] and picramic acid (II) [96-91-3] were detd. for rainbow trout. The bioconcn. factor (BCF) in the epaxial muscle at 42 days for both of these compds. was <1; the skin had a BCF value of 1 and 9, resp. The half-life elimination for the high and low dose of I was 12.0 and 12.5 days, resp.; for II, it was 9.0 and 9.5 days, resp. In sep. expts., ~34% of the injected [14C]I was metabolized to II glucuronide conjugates, and an unidentified group of compds., and 42% of the [14C]I was metabolized to I, glucuronide conjugates, and an unidentified group of compds. The low bioconcn. in the trout muscle may be due to the trout's ability to excrete the parent compd. and metabolites. The higher radioactivity obsd. on the skin may be due to the water route of exposure and the binding of the parent compds. to protein.

Uptake, elimination, and metabolism of 14C-picric acid and 14C-picramic acid in the American oyster (Crassostrea virginica)

Uptake, elimination, and metabolism of 14C-picric acid and 14C-picramic acid in the American oyster (Crassostrea virginica). Burton, Dennis T.; Cooper, Keith R.; Goodfellow, William L., Jr.; Rosenblatt, David H. (Appl. Phys. Lab., Johns Hopkins Univ., Shady Side, MD 20764, USA). Arch. Environ. Contam. Toxicol., 13(6), 653-63 (English) 1984. CODEN: AECTCV. ISSN: 0090-4341. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The oyster accumulated statistically significant amts. of 14C-labeled picric acid (I) [88-89-1] and picramic acid [96-91-3] above 2 exposure concns. in a biphasic uptake pattern. The 42-day 14C-accumulation factors (14C-AF) for American oysters continuously exposed to I concns. of 0.45 mg/L and 0.05 mg/L were 65.5 and 16.5, resp. Oysters exposed to 0.24 mg/L and 0.02 mg/L picramic acid had 42-day 14C-AFs of 49.3 and 86.8, resp. Steady state bioconcn. factors could not be calcd. (hence the use of the term 14C-AF), because 1) it is not clear that an equil. was reached for either I or picramic acid uptake during the 42 days of exposure, particularly for the high I and low picramic acid exposure concns., and 2) some of the parent compds. were metabolized to other compds. No statistically significant elimination of I was obsd. during the 14-day elimination study. Depuration of picramic acid was biphasic. Approx. 40% of the accumulated compd. was eliminated by the 2nd day of depuration during the initial phase for both the high and low concns. of picramic acid, whereas no elimination occurred during the secondary phase. A small percentage of I and picramic acid was metabolized by the oyster or its bacterial flora. There was no apparent difference between the concn. of the compds./g of tissue in the muscle gill, mantle, or body mass.