Reference

Hepatotoxic effect of several chloronitro derivatives of benzoic acid

Hepatotoxic effect of several chloronitro derivatives of benzoic acid. D'eng, B.; Nikolaev, A. Ya.; Khasigov, P. Z.; Likhachev, N. V.; Zaitseva, N. A.; Korolev, A. A. (I Mosk. Med. Inst., Moscow, USSR). Vopr. Med. Khim., 29(6), 113-17 (Russian) 1983. CODEN: VMDKAM. ISSN: 0042-8809. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The least toxic (oral LD50 in rats 4170 mg/kg) benzoic acid deriv. chlorobenzoic acid [26264-09-5] caused wavelike changes in the protein synthesis by liver: activation during 0.5-5 h following the administration, decrease in the synthesis from 6 to 33 h, sharp increase with max. at 60 h, and finally a redn. reaching the control value by the 8th day. Analogous changes were obsd. with the other 2 derivs. 9014-58-8 and 9013-75-6 are also in the experiment. 4-chloro-3-nitrobenzoic acid [96-99-1] and 3-nitrobenzoic acid [121-92-6]. Urokinase (EC 4.2.1.49) [9014-58-8] and histidase (EC 4.3.1.3) [9013-75-6] activities in the serum reached a max. by 15 h and remained at this level until 25 h. Activities of both of these decreased gradually but did not reach the control values until 70 h. Appearance of these enzymes in the blood indicate the hepatotoxic effects of these materials. A nonfractionated protein-synthesizing system, contg. S30 fraction, was quite sensitive to these materials and may be used for the study of hepatotoxicity of these compds. .

Ozone treatment of wastes containing polyfunctional aromatic compounds

Ozone treatment of wastes containing polyfunctional aromatic compounds. Carbini, M.; Buso, A.; Simioni, F.; Scipioni, A.; Navazio, G. (Fac. Ing., Univ. Padova, Padua, Italy). AES, 6(8), 40-4 (Italian) 1984. CODEN: AESIDB. ISSN: 0391-7339. DOCUMENT TYPE: Journal CA Section: 60 (Waste Treatment and Disposal) Polyfunctional arom. hydrocarbons which are biol. refractive are treated by ozonization to form compds. which can be biodegraded. Thus, COD from m-benzenedisulfonic acid [98-48-6], 4-chloro-3-nitrobenzoic acid [96-99-1], and 4-chloro-3,5-dinitrobenzoic acid [118-97-8] were reduced from >4000, >6000, and >2500 ppm to <500, ~750, and <500 ppm after 120 min of ozonization.