Reference

A comparative study in vitro of antibacterial activities of 3 carbapenem antibiotics and their therapeutic efficacies against pulmonary infection

All Rights Reserved. A comparative study in vitro of antibacterial activities of 3 carbapenem antibiotics and their therapeutic efficacies against pulmonary infection. Li, Junmei; Liu, Gang; Yang, Heping; He, Juying; Li, Xuejun; Liu, Songqing; Liu, Ping; Hu, Jianlin (Southwest Hospital, Third Military Medical University, Chongqing 400038, Peop. Rep. China). Di-San Junyi Daxue Xuebao, 27(13), 1391-1393 (Chinese) 2005 Di-San Junyi Daxue Xuebao Bianjibu. CODEN: DYXUE8. ISSN: 1000-5404. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) Section cross-reference(s): 1 The MICs of panipenem/betamipron, imipenem/cilastatin and meropenem to 242 clin. isolates were detd. by means of agar diln. method and their min. bactericidal concns. (MBCs) to some clin. isolates were detd. to est. their therapeutic effects on pulmonary infection.Several reagents with their cas registry numbers 92309-29-0 and 96036-03-2 are used here. Twenty, 18, and 16 cases with pulmonary infection were treated with i.v. drip of panipenem/betamipron, imipenem/cilastatin and meropenem, resp., at a dose of 500 mg/12 h for 3 to 7 days. Meanwhile, bacteria culture was conducted and the efficacy of the drugs was consecutively evaluated. Panipenem/betamipron, imipenem/cilastatin and meropenem were all powerful antibiotic agents against the broad antibacterial spectrum of both Gram-pos. and Gram-neg. bacteria in clin. isolates. The in vitro antimicrobial activities of the 3 carbapenems was similar. The bactericidal effects of panipenem/betamipron on gram-pos. bacteria were superior to that of imipenem/cilastatin and meropenem. The antimicrobial activity of meropenem on Gram-neg. bacteria was superior to that of the other 2 in vitro. The eradication rate of bacteria treated with panipenem/betamipron, imipenem/cilastatin and meropenem was 80.9%, 89%, and 94%, resp., and their effective healing rate was 75%, 83%, and 88%, resp. No severe adverse reaction was obsd., and no statistical differences among three groups were obsd. Panipenem/betamipron, imipenem/cilastatin and meropenem were all powerful antibiotic agents against both Gram-pos. and Gram-neg. bacteria from clin. isolates. The 3 carbapenems had similar antimicrobial activity in vitro and were effective and safe in treating pulmonary infection. .

Examination of cfiA-mediated carbapenem resistance in Bacteroides fragilis strains from a European antibiotic susceptibility survey

All Rights Reserved. Examination of cfiA-mediated carbapenem resistance in Bacteroides fragilis strains from a European antibiotic susceptibility survey. Soki, J.; Edwards, R.; Hedberg, M.; Fang, H.; Nagy, E.; Nord, C. E. ( Institute of Clinical Microbiology, Faculty of General Medicine, University of Szeged, Szeged H-6725, Hung.). International Journal of Antimicrobial Agents, 28(6), 497-502 (English) 2006 Elsevier B.V. CODEN: IAAGEA. ISSN: 0924-8579. DOCUMENT TYPE: Journal CA Section: 10 (Microbial, Algal, and Fungal Biochemistry) Of 1284 Bacteroides strains collected in Europe in 2000 for antibiotic susceptibility surveillance, 65 isolates displayed imipenem min. inhibitory concns. (MICs) 31 mg/L and were chosen for a thorough anal. of their resistance mechanism. Twenty-five of the isolates were pos. for the cfiA carbapenem resistance gene. The resistance rates were 0.8% and 1. 96036-03-2 and 923358-34-3 which are cas registry numbers of substances are two of reagents here.3% for imipenem and meropenem, resp. In six of the strains, insertion sequence (IS) elements (IS613, IS614B, IS1186 and IS1187) activated the cfiA gene. However, other strains displayed at least elevated carbapenem MICs or were carbapenem resistant and produced measurable carbapenemase activities but did not harbor IS elements in the region upstream of the cfiA gene. The major determinant of carbapenem resistance in Bacteroides fragilis is prodn. of CfiA metallo-b-lactamase via activation of the cfiA gene by IS elements (higher level resistance) or by activation of its putative own promoter. .