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| CAS No.: | 968-81-0 |
|---|---|
| Name: | ACETOHEXAMIDE |
| Molecular Structure: | |
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| Formula: | C15H20 N2 O4 S |
| Molecular Weight: | 324.401 |
| Synonyms: | Urea,1-[(p-acetylphenyl)sulfonyl]-3-cyclohexyl- (6CI,8CI);1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea;1-[(p-Acetylphenyl)sulfonyl]-3-cyclohexylurea; Acetohexamid; Acetohexamide;Dimelin; Dimelin (antidiabetic); Dimelor; Dymelor; Gamadiabet; Hypoglicil;Metaglucina; Minoral; N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea; Ordimel;Tsiklamid; U 14812 |
| Density: | 1.3g/cm3 |
| Melting Point: | 188-190° (GB 912789); mp 175-177° (Marshall) |
| Solubility: | 0.25g/L(25 oC) |
| Safety: | Human reproductive effects by an unspecified route: stillbirth. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of SOx and NOx. |
| PSA: | 100.72000 |
| LogP: | 4.07240 |
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Chemistry
Product Name: Acetohexamide (CAS NO.968-81-0)
Molecular Formula: C15H20N2O4S
Molecular Weight: 324.4g/mol
Mol File: 968-81-0.mol
Einecs: 213-530-4
Appearance: White fluffy crystalline powder with almost no odor
Density: 1.3 g/cm3
Solubility: DMSO: 45 mg/mL
Surface Tension: 55.7 dyne/cm
XLogP3: 2.4
H-Bond Donor: 2
H-Bond Acceptor: 4
Uses
Acetohexamide (CAS NO.968-81-0) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.It lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must produce insulin for this medication to work. For this reason, acetohexamide is not used to treat diabetes mellitus type 1.
Production
First be obtained on the amino-acetyl-benzene-acetyl benzene sulfonamide, and then continue to work with cyclohexyl isocyanate reaction of vinegar and sulfur ring has been urea
Toxicity Data With Reference
| 1. | unr-wmn TDLo:900 mg/kg (26-39W preg):REP | BMJOAE British Medical Journal. 2 (1964),187. | ||
| 2. | orl-rat LD50:5000 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),185. |
Consensus Reports
NCI Carcinogenesis Bioassay (feed); No Evidence: mouse, rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-50 ,1978. . Reported in EPA TSCA Inventory.
Safety Profile
Human reproductive effects by an unspecified route: stillbirth. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Safety Information of Acetohexamide (CAS NO.968-81-0):
Safety Statements: 36
36: Wear suitable protective clothing
Specification
Acetohexamide ,its CAS NO. is 968-81-0,the synonyms is 4-Acetyl-n-[(cyclohexylamino)-carbonyl]benzenesulfonamide ; Acetohexamide ; 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexyl-ure ; 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea ; 1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea ; 4-Acetyl-n-((cyclohexylamino)carbonyl)-benzenesulfonamid ; 4-Acetyl-n-[(cyclohexylamino)carbonyl]-benzenesulfonamid ; 4-Acetyl-n-benzenesulfonamide .