CAS No.968-93-4,2H-Phenanthro[2,1-b]pyran-2,8(4bH)-dione,3,4,4a,5,6,10a,10b,11,12,12a-decahydro-10a,12a-dimethyl-,(4aS,4bR,10aR,10bS,12aS)- Suppliers

Detail of "968-93-4"

CAS Number:

968-93-4

Name:

2H-Phenanthro[2,1-b]pyran-2,8(4bH)-dione,3,4,4a,5,6,10a,10b,11,12,12a-decahydro-10a,12a-dimethyl-,(4aS,4bR,10aR,10bS,12aS)-

Superlist Name:

Testolactone

Molecular Structure:

Formula:

C₁₉H₂₄O₃

Molecular Weight:

300.39

Synonyms:

13,17-Secoandrosta-1,4-dien-17-oicacid, 13-hydroxy-3-oxo-, d-lactone (6CI,8CI);D-Homo-17a-oxaandrosta-1,4-diene-3,17-dione;Testololactone, 1-dehydro- (7CI);1,2-Dehydrotestololactone;1,2-Didehydrotestololactone;1-Dehydrotestololactone;17a-Oxa-D-homo-1,4-androstadiene-3,17-dione;2H-Phenanthro[2,1-b]pyran-2,8(4bH)-dione,3,4,4a,5,6,10a,10b,11,12,12a-decahydro-10a,12a-dimethyl-, [4aS-(4aa,4bb,10ab,10ba,12ab)]-;Testolacton;D1-Dehydrotestololactone;D1-Testololactone;

EINECS:

213-534-6

Density:

1.17 g/cm³

Boiling Point:

482 °C at 760 mmHg

Flash Point:

213.4 °C

Reference

Testolactone: Testolactone. Florey, Klaus (Squibb Inst. Med. Res., New Brunswick, N. J., USA). Anal. Profiles Drug Subst., 5, 533-53 (English) 1976. CODEN: APDSB7. DOCUMENT TYPE: Journal; General Review CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 64, 32 A review with 36 refs. of testolactone (I) [968-93-4], giving its phys. properties, synthesis, metab., stability, degrdn., methods of anal., and detn. in pharmaceutical prepns.

Aromatase inhibition by D1-testolactone does not relieve the gonadotropin-induced late steroidogenic block in normal men: Aromatase inhibition by D1-testolactone does not relieve the gonadotropin-induced late steroidogenic block in normal men. Smals, A. G. H.; Dony, J. M. J.; Smals, A. E. M.; Pieters, G. F. F. M.; Hermus, A. R. M. M.; Boers, G. H. J.; Benraad, T. J.; Kloppenborg, P. W. C. (Dep. Med., Univ. Nijmegen, Nijmegen, Neth.). J. Clin. Endocrinol. Metab., 60(6), 1127-31 (English) 1985. CODEN: JCEMAZ. ISSN: 0021-972X. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Aromatase inhibition by D1-testolactone [968-93-4] 500 mg twice daily for 10 days in normal men lowered circulating estradiol (E2) [50-28-2] levels by ~25%, enhanced the secretion of FSH [9002-68-0], 17-hydroxyprogesterone (17-OHP) [68-96-2], and to a lesser degree testosterone (T) [58-22-0], but did not affect serum LH levels. Despite E2 lowering there was greater accumulation of 17-OHP than of T after 7 days of treatment, suggesting 17,20-lyase [9044-50-2] inhibition. Unexpectedly, administration of D1-testolactone almost halved the T response to human chorionic gonadotropin [9002-61-3] (hCG) (Pregnyl, 1500 IU), but did not affect the 17-OHP response. Thus, E2 lowering by testolactone aggravated the hCG-induced 17,20-lyase block present before testolactone administration. Although the present data might suggest that estrogens do not play a role in the genesis of the hCG-induced late steroidogenic block, the results suggest that testolactone per se, in addn. to its reported antiestrogenic action, inhibits 17,20 lyase.

Detail of "968-93-4"

2H-Phenanthro[2,1-b]pyran-2,8(4bH)-dione,3,4,4a,5,6,10a,10b,11,12,12a-decahydro-10a,12a-dimethyl-,(4aS,4bR,10aR,10bS,12aS)-

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CAS No.968-93-4 Testolactone

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Reference