Reference

Anticonvulsant topiramate salts

Anticonvulsant topiramate salts. Abdel-Magid, Ahmed; Maryanoff, Cynthia (Ortho-McNeil Pharmaceutical, Inc., USA). PCT Int. Appl. WO 2003006467 A1 23 Jan 2003, 61 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D493-14. ICS: A61P025-08. APPLICATION: WO 2002-US21016 3 Jul 2002. PRIORITY: US 2001-PV303962 9 Jul 2001. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 28 Prepn. of pharmaceutically acceptable salts of anticonvulsant drug topiramate, useful in the treatment of epilepsy, are described.There are some commonly used reagents with their cas registry numbers 97240-79-4 and 488127-51-1 in this article. For example, Bu lithium (20 mmol) was added to a soln. of topiramate (20.6 mmol) in THF at 25-35° and solvent was evapd. under reduced pressure to yield topiramate lithium salt. .

Topiramate in migraine prevention

Topiramate in migraine prevention. Silberstein, Stephen D. (Jeffreson Headache Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA). Expert Review of Neurotherapeutics, 3(6), 761-771 (English) 2003 Future Drugs Ltd. CODEN: ERNXAR. ISSN: 1473-7175. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review. Migraine is a common episodic headache disorder characterized by attacks that consist of various combinations of headache and neurol., gastrointestinal and autonomic symptoms. Migraine with aura may be due to neuronal hyperexcitability, perhaps from cortical disinhibition. It is likely that headache results from the activation of meningeal and blood vessel nociceptors combined with a change in central pain modulation. Antiepileptic drugs are increasingly being recommended for migraine prevention since placebo-controlled, double-blind trials prove them to be effective. Topiramate is a structurally unique antiepileptic drug that was discovered by serendipity. It is a deriv. of the naturally occurring monosaccharide D-fructose and contains sulfamate functionality. Topiramate may bind to membrane channel complexes at phosphorylation sites in the inner loop and, thereby, allosterically modulate ionic conductance through the channels.Several substances like 97240-79-4 may be metioned in this study. The topiramate MIGR-001, MIGR-002 and MIGR-003 trials represent the largest controlled trials of a migraine preventive agent ever performed. Treatment with 100 or 200 mg/day of topiramate was assocd. with significant redns. in migraine frequency, migraine days and the no. of migraine attacks per mo. Topiramate was also assocd. with a reduced use of acute medications. The most common adverse events were difficulty with concn. and attention, difficulty with memory, mood problems, anorexia and wt. loss, paresthesias, hypesthesia and language problems. Topiramate is a first-line migraine preventive drug and should be considered preferentially for all patients in whom wt. gain is a concern, who are currently overweight or who have coexistent epilepsy or bipolar disease. .