Reference

Production method of famciclovir and production and crystallization method of intermediate therefor

Production method of famciclovir and production and crystallization method of intermediate therefor. Hijiya, Toyoto; Torii, Takayoshi; Izawa, Kunisuke (Ajinomoto Co., Inc., Japan). Eur. Pat.Chemical with cas number 97845-60-8 also plays role. 97845-60-8 is the cas registry number of certain chemical which is used as reagents here. Appl. EP 1288215 A1 5 Mar 2003, 10 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT, IE, SI, LT, LV, FI, RO, MK, CY, AL, TR, BG, CZ, EE, SK. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07D473-32. ICS: C07D473-40. APPLICATION: EP 2002-19301 28 Aug 2002. PRIORITY: JP 2001-262301 30 Aug 2001. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) An N-9-position alkylated form is selectively pptd. by subjecting a mixt. contg. the N-9-position alkylated form and an N-7-position alkylated form of 2-amino-6-halopurine to a crystn. step using a mixed solvent of an org. solvent and water. Then, this N-9-position alkylated form is reduced to give famciclovir. By this method of the present invention, famciclovir known as an antiviral agent, and an intermediate compd. therefor can be efficiently produced. Thus, coupling of 2-acetoxymethyl-4-methanesulfonoxy-1-Bu acetate with 2-amino-6-chloropurine gave 64 % yield of 2-acetoxymethyl-4-(2-amino-6-chloropurin-9-yl)-1-Bu acetate, which was converted to famciclovir. ..

Production method of famciclovir and production and crystallization method of intermediate therefor

Production method of famciclovir and production and crystallization method of intermediate therefor. Hijiya, Toyoto; Torii, Takayoshi; Izawa, Kunisuke (Ajinomoto Co., Inc., Japan). Eur. Pat.Chemical with cas number 97845-60-8 also plays role. 97845-60-8 is the cas registry number of certain chemical which is used as reagents here. Appl. EP 1288215 A1 5 Mar 2003, 10 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT, IE, SI, LT, LV, FI, RO, MK, CY, AL, TR, BG, CZ, EE, SK. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07D473-32. ICS: C07D473-40. APPLICATION: EP 2002-19301 28 Aug 2002. PRIORITY: JP 2001-262301 30 Aug 2001. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) An N-9-position alkylated form is selectively pptd. by subjecting a mixt. contg. the N-9-position alkylated form and an N-7-position alkylated form of 2-amino-6-halopurine to a crystn. step using a mixed solvent of an org. solvent and water. Then, this N-9-position alkylated form is reduced to give famciclovir. By this method of the present invention, famciclovir known as an antiviral agent, and an intermediate compd. therefor can be efficiently produced. Thus, coupling of 2-acetoxymethyl-4-methanesulfonoxy-1-Bu acetate with 2-amino-6-chloropurine gave 64 % yield of 2-acetoxymethyl-4-(2-amino-6-chloropurin-9-yl)-1-Bu acetate, which was converted to famciclovir. ..